Various forms of oncogenic ALK proteins have been identified in various types of human cancers. While Crizotinib, an ALK inhibitor, has been found to be therapeutically useful against a subset of ALK(+) tumours, clinical resistance to this drug has been well recognized and the mechanism of this phenomenon is incompletely understood. Using the cellular thermal shift assay (CETSA), we measured th...

CSR is basically very important to be applied companies. The company's activities will have a positive impact because companies that implement able attract the attention of consumers so they can influence image consumers. aim study determine effect on financial performance manufacturing listed Indonesia Stock Exchange (IDX) by using ROA, ROE, and NPM as proxy for performance. method used select...

This article reviews the New Public Management (NPM) literature in Central and Eastern Europe, looking particularly at reforms in Estonia, Hungary and Romania. It finds that research that assessed changes in internal processes and activities within the public sector by far outnumber research that assessed changes in outputs and outcomes. Overall more studies have found positive than negative ef...

In this study we investigated the relevance of the oncogenic protein NPM-ALK in regulating cellular pH (pHi) through the modulation of Na+/H+ exchanger 1 (NHE1)-activity and the consequences of pHi pharmacological manipulation in cells expressing NPM-ALK.

NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To determine if t(2;5) is involved in cutaneous lymphoproliferative disorders, we studied 37 CD30+ cutaneous lymphoproliferations, 27 mycosis fungoides (MF), and 16 benign inflammatory disorders (BID). NPM-ALK transcripts were detected by nested reverse transcription-polymeras...

Core-polymerized and boron-conjugated micelles (PM micelles) were prepared by free radical copolymerization of a PEG-b-PLA block copolymer bearing an acetal group and a methacryloyl group (acetal-PEG-b-PLA-MA), with 1-(4-vinylbenzyl)-closo-carborane (VB-carborane), and the utility of these micelles as a tumor-targeted boron delivery system was investigated for boron neutron capture therapy (BNC...

Prions are proteins most commonly associated with fatal neurodegenerative diseases in mammals but are also responsible for a number of harmless heritable phenotypes in yeast. These states arise when a misfolded form of a protein appears and, rather than be removed by cellular quality control mechanisms, persists. The misfolded prion protein forms aggregates and is capable of converting normally...

Cytotoxic lymphocyte protease GrM (granzyme M) is a potent inducer of tumour cell death and a key regulator of inflammation. Although hGrM (human GrM) and mGrM (mouse GrM) display extensive sequence homology, the substrate specificity of mGrM remains unknown. In the present study, we show that hGrM and mGrM have diverged during evolution. Positional scanning libraries of tetrapeptide substrates...

We describe the use of the Lick Northern Proper Motion (NPM) program and its southern-sky complement, the Yale/San Juan Southern Proper Motion (SPM) program, to determine the Hipparcos proper motion link to the extragalactic reference system defined by galaxies. In total ∼9,100 Hipparcos stars were chosen for the NPM link solution and ∼4,100 for the SPM solution. The typical accuracy of the NPM...