BACKGROUND Alcoholism is a widespread chronic disorder of complex aetiology with a significant negative impact on the individual and the society. Mechanisms of ethanol action are not sufficiently well understood at the molecular level and the pharmacotherapy of alcoholism is still in its infancy. Our study focuses at the cellular and molecular level on ethanol-induced effects that are mediated ...

Abstract Irrigation works aim to increase the efficiency of water use and economic benefits for farmers. This study adopts a broader view investigates their potential contribute achievement other sustainability objectives. In particular, paper employs multi-objective programming (MOP) model, which examines possibilities simultaneously achieving four conflicting objectives with upgrade an irriga...

Today, many dialects of traditional programming languages exist [6]. In most cases, they add some programming paradigm or functionality to the original language. A major drawback of these dialects is that they have hard coded the extensions into the compiler. In an open mechanism, programmers may introduce extensions to the language to t their own development needs. Otherwise every extension re...

BACKGROUND (-)-Pentazocine has been hypothesized to induce analgesia via the κ-opioid (KOP) receptor, although the involvement of other opioid receptor subtypes in the effects of pentazocine remains unknown. In this study, we investigated the role of the μ-opioid (MOP) receptor in thermal, mechanical, and chemical antinociception induced by (-)-pentazocine using MOP receptor knockout (MOP-KO) m...

In practice, there are many problems which decision parameters are fuzzy numbers, and some kind of this problems are formulated as either possibilitic programming or multi-objective programming methods. In this paper, we consider a multi-objective programming problem with fuzzy data in constraints and introduce a new approach for solving these problems base on a combination of the multi-objecti...