PURPOSE Whereas the Kasai portoenterostomy (KPE) is an accepted first line of surgery for bile drainage in infants with biliary atresia, its long-term effectiveness is not clear because its etiology and pathogenesis remains unknown. This study was aimed to investigate the late complications occurring in long-term survivors and the current status of living patients who survived over 10 years aft...

Serum carcinoembryonic antigen (s-CEA) is used to detect recurrence and predict prognosis in colorectal cancer. However, the cutoff values of s-CEA for prognosis have not been determined. We therefore tried to determine the preoperative s-CEA levels predictive of survivals in colorectal cancer patients. We retrospectively analyzed the medical records of 989 patients who underwent curative resec...

Flavio MILANA*, Matteo DONADON, Michela Anna POLIDORO, Cristiana SOLDANI, Barbara FRANCESCHINI, Guido TORZILLI. Ann Hepatobiliary Pancreat Surg 2023;27:S167. https://doi.org/10.14701/ahbps.2023S1.LV-PP-1-2

BACKGROUND & OBJECTIVES The quality of life (QOL) of substance abusers is known to be severely impaired. Information on impact of opioid maintenance treatment on the QOL of opioid dependent subjects though available from the developed countries, is lacking from India. This study was carried out to assess the impact of buprenorphine maintenance treatment on the quality of life (QOL) of opioid de...

The effectiveness of modified-directly observed therapy (m-DOT), an adherence support intervention adapted from TB DOTS programmes, has been documented. Describing the implementation process and acceptability of this intervention is important for scaling up, replication in other settings and future research. In a randomised trial in Mombasa, Kenya, patients were assigned to m-DOT or standard of...

Maximum likelihood and related techniques are generally considered the best method for estimating the parameters of spatial models, but exact computation of the likelihood is slow when the number of data points is large. For Gaussian models with parametrically specified covariance function, we consider three alternatives to the exact maximum likelihood estimates that are easier to compute. Stat...

In this paper we look at how information in societies is organized and how power relationships arise as a consequence of this organization. We argue that many of the observed information asymmetries are not happenstance and, drawing from a wealth of scholarship from the economics and finance literature, we posit that outcomes are inevitably detrimental. The paper concentrates on the techniques ...

OBJECTIVES To investigate the association between clinical need and hospital bed supply and utilization in Russia; and, to investigate these associations in areas where traditional Russian tuberculosis health care systems exist and where the directly observed therapy-short course (DOTS) strategy has been implemented. DESIGN Ecological study using 2002 routine data. MAIN OUTCOME MEASURES Hos...

Hormesis has been defined as a dose-response relationship in which there is a stimulatory response at low doses, but an inhibitory response at high doses, resulting in a U- or inverted U-shaped dose response. To assess the proportion of studies satisfying criteria for evidence of hormesis, a database was created from published toxicological literature using rigorous a priori entry and evaluativ...