The occurrence of mycotoxigenic species in peanuts is a major concern, and has been investigated depth for many years. However, most studies focus on the aflatoxigenic fungi, such as Aspergillus section Flavi. present study aimed to clarify Nigri, group that harbors capable producing ochratoxin A (OTA), which scarcely peanuts. total 52 peanut samples, collected field from storage, were analyzed...

Abstract: This paper presents a new general synthesis method for high-order current mode Operational Transconductance Amplifiers and Capacitors, (OTA-C) filters. The method is based on the analytical solution of a single, nth-order generic filter transfer function and the generation of n, number of realizable transfer functions implemented using lossless integrators. The method provides systema...

Ochratoxin A (OTA), a potentially carcinogenic mycotoxin which contaminates grains, is produced by several Aspergillus species. A comparative sequence analysis of the OTA-producing Aspergillus ochraceus fc-1 strain and other Aspergillus species was performed. Two new OTA-related polyketide synthase (PKS) (AoOTApks) genes were identified. The predicted amino acid sequence of AoOTApks-1 displayed...

Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus and Penicillium genera. It hepatotoxic, nephrotoxic carcinogenic. The growing contamination of OTA in wine grape juice great threat to human. In this study, different enzymes were screened for the detoxification juice. results indicated that seven had degradation capacity buffer, rate carboxypeptidase (CPA), lipase, pancreatin thermolysi...

Ochratoxin A (OTA) is a secondary fungal metabolite that enters the food chain by cereals, beer and other products. Its toxicity is an important aim regarding the human pathologies such as nephrotoxicity. This mechanism is intense studied because of the affinity for blood albumins and the renal accumulation by the organic anion transporter. Its serum half-life is different in humans (850 h) and...

Mycotoxins, such as ochratoxin A (OTA), can occur from fungal growth on foods. OTA is considered a possible risk factor for adverse renal effects in humans based on renal tumors in male rats. For risk mitigation, Health Canada proposed maximum limits (MLs) for OTA based largely on a comparative risk assessment conducted by Health Canada (Kuiper-Goodman et al., 2010), in which analytical data of...

Ochratoxin A (OTA), a mycotoxin, is a potent nephrotoxin in humans and animals. Selenium (Se) is an essential micronutrient for humans and animals, and plays a key role in antioxidant defense. To date, little is known about the effect of Se on OTA-induced nephrotoxicity. In this study, the protective effects of selenomethionine against OTA-induced nephrotoxicity were investigated using the porc...

In the present study an in vitro model of subchronic repeated exposure to OTA and OTB was employed to generate ochratoxin-derived subpopulations of human and porcine proximal tubular cells (HKC, IHKE, PKC, LLC-PK1). These cell subpopulations were subsequently used to investigate effects on cell proliferation rates, expression of marker proteins (cytokeratins, vimentin) and the acute cytotoxicit...

Ochratoxin A (OTA) is nephrotoxic, hepatotoxic, immunotoxic, neurotoxic, reprotoxic, teratogenic, and carcinogenic (group 2B), being characterized by species and sex differences in sensitivity. Despite the fact that OTA is in some aspects a controversial topic, OTA is the most powerful renal carcinogen. The aim of this study was to make a small survey concerning OTA content in black tea, fruit ...

Simultaneous contamination of ochratoxin A (OTA) and aflatoxin B1 (AFB1) in cereals are an ongoing global concern. For this reason, a sensitive method for the simultaneous detection OTA AFB1 soybean, corn, rice is required. Herein, we prepared bispecific monoclonal antibody (BsMAb) that specifically recognized AFB1, subsequently developed quantum dot nanobead (QB) lateral flow immunoassay (QB-L...