The cornea is one of the most densely innervated and sensitive tissues in the body. In addition to their important sensory functions, corneal nerves induce reflex tear production, blinking, and the release of trophic factors - all of which combined help to maintain the structural and functional integrity of the surface of the eye. Consequently, damage to corneal nerves as a result of disease, s...

TOPIC The clinical features and management strategies for varicella-zoster virus (VZV) infections of the cornea, lids, and adnexa. CLINICAL RELEVANCE Herpes zoster ophthalmicus (HZO) can result in a myriad of chronic and recurrent complications that may be sight threatening. Surgical intervention is the mainstay of treatment, and advancements in this area may lessen the complications of HZO i...

A previously healthy 30-year-old man presented with gradually worsening oscillopsia 2 weeks after an unusual headache; there was ocular flutter on examination (video on the Neurology® Web site at www.neurology.org) without other findings. Brain MRI was unremarkable. CSF showed mild pleocytosis (11 cells/mm), but no evidence of active viral infections (herpes simplex virus, cytomegalovirus, vari...

Feline herpesvirus 1 (FeHV-1) is an alphaherpesvirus that causes feline viral rhinotracheitis, an important viral disease of cats on a worldwide basis. Acute FeHV-1 infection is associated with both upper respiratory and ocular signs. Following the acute phase of the disease lifelong latency is established, primarily in sensory neuronal cells. As is the case with human herpes simplex viruses, l...

1 Pathology and Clinical Laboratory Medicine, Department of Immunology, King Fahad Medical City, Riyadh 11525, Saudi Arabia 2Laboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, College of Medicine, University of California, Irvine, CA 92697-4375, USA 3 INSERM U 1058, Université Montpellier 1, 34090 Montpellier, France 4Department of Pathology andMolecular Medicine, McM...