rehabilitation of facial defects is a complex task, requiring an individualized design of the technique for each patient. the disfigurement associated with the loss of an eye may result in significant physical and emotional problems. various treatment modalities are available, one of which is the use of implants. although implant-supported orbital prosthesis has a superior outcome, it may not b...

sulfur mustard, a bifunctional alkylating agent, causes severe eye injury. the injury is a result of late inflammation, which is mediated by prostaglandins. theoretically, inhibition of prostaglandins by reagents such as indomethacine could result in alleviation of clinical adverse effects. in this study, the protective effect of topically applied indomethacine against sulfur mustard toxicity w...

objective the prevalence of syphilis is increasing in the world. although ocular syphilis is not a common presentation of syphilis, it occurs in 2.5 to 5% of patients with tertiary syphilis and less than 1% of patients with untreated late syphilis. patient we report a 58-year-old man presented with a 3-month history of decreased vision. he developed neurosensory detachment, retinitis and panuve...

dirofilariasis is caused by a filariid parasite of the genus dirofilaria. this zoonotic infection is spread by mosquito vector from animal to human. ocular dirofilariasis involving the eye and adnexa is rare. a nodule in the right eye had developed in a 20-year-old soldier from mazandaran province, north of iran. the mass was removed surgically and measured 5x5 mm. the specimen was identified o...

Ultrasound-guided in utero injections into the brain of murine embryos has been shown to facilitate gene delivery. We investigated whether these methods would allow gene transfer into ocular structures. Gene transfer using retroviral vectors or electroporation was found to be quite effective. We determined the window of time, as well as compared several strains of mice, that yield a high degree...

The introduction of new antibiotic compounds into therapy initiates the development of resistance by the target bacteria. Resistance increases the risk of treatment failure with potentially serious consequences. Local application of antibacterial compounds to the eyes may lead to bacterial resistance in bacterial isolates from the eyes. The incidence of resistant strains of common pathogens is ...

The extracellular matrix (ECM) is responsible for many of the cell behavior processes, including cell proliferation and growth, survival, change in cell shape, migration, and differentiation. The most important component of the ECM is heparan sulfate (HS), because it insures the storage of many cell communication proteins, necessary for the continuous and identical renewal of cells and thus for...

As a result of improved treatment and patient survival, ophthalmic complications are now being seen with increasing frequency in AIDS, occurring in up to 75% of patients during the course of the disease. The eye may be involved by an AIDS-related microvasculopathy, which gives rise to cotton wool spots, and by opportunistic infections caused by a wide range of organisms, including cytomegalovir...

Proton beam therapy (PBT) is an advanced type of radiotherapy that shows a dosimetric advantage over photon and provides superior dose distribution. PBT may improve patient survival by improving the local disease control while reducing toxicity to normal organs, which result in fewer treatment-related complications. During last decade, technological progress has opened up new possibilities plan...