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BACKGROUND Renal renin-angiotensin system (RAS) activation is one of the important pathogenic mechanisms in the development of diabetic nephropathy in type 2 diabetes. The aim of this study was to investigate the effects of a sodium-glucose co-transporter 2 (SGLT-2) inhibitor, dapagliflozin, on renal RAS in an animal model with type 2 diabetes. METHODS Dapagliflozin (1.0 mg/kg, OL-DA) or vogl...
Abstract By monitoring biomarkers in urine, personal exposure to selected chemical substances can be assessed. In this paper, we describe the of 7 benzophenone and 2 camphor UV-filters 11 metabolites polycyclic aromatic hydrocarbons (OH-PAHs) 454 urine samples collected from mothers new-borns an industrial (Karvina) reference area (Ceske Budejovice) over winter summer seasons. The analytical me...
A constructive method for investigating if a given nonlin-ear dynamic system subject to control constraints can be controlled to follow a desired curve in the state or output space is presented. If the method gives an aarmative answer we can compute a closed form expression of the corresponding state feedback control law. Specifying a family of parametrized curves, approximations of reachable s...
Presilphiperfolanols (also known as prebotrydials) are members of a family of natural products that are important biosynthetic precursors to diverse sesquiterpenoids (Figure 1).[i, ii, iii, iv] To date, four members of the group have been isolated: presilphiperfolan-1-ol (1),[v] 9-epi-presilphiperfolan-1-o l (2),[vi] presilphiperfolan-8-ol (3),[ii] and presilphiperfolan-9-ol (4),[vii] with 1 an...
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