Large numbers of branched muscle fibers occur in the freely grafted rat extensor digitorum longus muscle. The ratio of branched/non-branched muscle fibers in grafts is much higher in old (24 months) than in young (4 months) host rats. Crossage transplants show that the proportion of branched muscle fibers is related to the age of the grafted muscle and not to the age of the host. This is in con...

A rare case of a gynecologic type leiomyoma with amianthoid-like fibers is presented. The 6 cm tumor was found in the uterus of a 46-year-old woman. Histologically, it contained a cellular spindle cell population with numerous eosinophilic amianthoid-like fibers. The morphology closely resembled that of palisaded "amianthoid" myofibroblastoma. Immunohistochemically, the lesion showed a smooth m...

Prof. Leslie asks how the variable for TV-newspaper crossownership applies to non-local newspapers. Owners of TV stations that do not own a local newspaper in the same market are not considered to be cross-owned in this analysis, even if they own a national newspaper or a newspaper local to another market. This definition is based on the legal definition of crossownership adopted by the FCC, an...

A 12-year-old boy with difficulty in wound healing and abnormal scars since early childhood was examined. Light microscopy showed loose and disperse dermal collagen with rare bundles, and fibroblasts show an irregular morphology. The fibrous sheath of hair presented a normal parallel distribution of the collagen fibers with normal spindle-shaped fibroblasts. Transmission electron microscopy als...

We report the ultrastructural findings in a case of a 72-year-old black woman with confluent yellowish papules in the cervical region. She had no comorbidities. Ophthalmological examination, electrocardiogram, and echocardiogram were normal. Hematoxylin-eosin staining of the affected skin showed strong alterations in the mid-dermis with irregular clumps of eosinophilic material and loss of the ...

Psychopathy is a condition that has long captured the public imagination. Newspaper column inches are devoted to murderers with psychopathic features and movies such as No Country for Old Men and We Need to Talk About Kevin focus on characters who are exceptionally cold and callous. Psychopathy is in fact a personality disorder characterised by lack of empathy and guilt, shallow affect, manipul...

We examined the effects of mild therapeutic exercise during a period of inactivity on size and contractile functions of myosin heavy chain (MHC) type I (n = 204) and type II (n = 419) single fibers from the medial gastrocnemius in three age groups. Young adult (5-12 mo), middle-aged (24-31 mo), and old (32-37 mo) F344BNF1 rats were assigned to one of three groups: weight-bearing control, non-we...

We report an observation of uncommon form extra-papillary myelin fibers fortuitous discovery in a patient, 55 years old, who consulted for change correction. The clinical aspect the fundus led to diagnosis retinal front whitish placard with finely striated scalloped edge, partially masking vessels and located at level inferior temporal arch. These fibers, contiguous papilla or distant from it, ...

We have studied the strain-rate dependency of the viscoelastic mechanical properties of human dermis from young (23-year-old) and old (87-year-old) donors using incremental stress–strain measurements. The elastic spring constant for elastic fibers was found to be strain-rate and age dependent, whereas that for collagen was only age dependent. Fibril lengths were observed to decrease with increa...

Using an in vitro nerve skin preparation and controlled mechanical or thermal stimuli, we analyzed the receptive properties of 277 mechanosensitive single primary afferents with myelinated (n = 251) or unmyelinated (n = 26) axons innervating the hairy skin in adult or 2-wk-old mice. Afferents were recorded from small filaments of either sural or saphenous nerves in an outbred mice strain or in ...