INTRODUCTION Olfactory dysfunction is an early and common symptom in idiopathic Parkinson's disease (IPD). Recently, the relation between olfactory dysfunction and cognitive loss in IPD has been reported. In our study, we aimed to investigate the relation between olfactory dysfunction and cognitive impairments in early IPD related with this theory. METHODS In this study, we included 28 patien...

Usher syndrome (USH), the most frequent type of hereditary combined deafness and blindness in adults, represents a heterogenous group of autosomal-recessive disorders characterized by congenital sensorineural hearing loss (SNHL), retinitis pigmentosa (RP), and, in some cases, vestibular dysfunction. The standard classification of this multisensory disease usually recognizes two distinct clinica...

CONCLUSION Daily intranasal perfusion of lipopolysaccharide (LPS) for 14 days in rats induced apoptosis of olfactory receptor neurons (ORNs) over >3 but <7 days. OBJECTIVES Smoking is one of the factors causing olfactory dysfunction. LPS is a major glycolipid component of the gram-negative bacterial cell wall and an active component of cigarette smoke. We studied whether LPS is one of the cau...

Olfactory dysfunction is present in up to 90% of Alzheimer's disease (AD) patients. Although deposition of hyperphosphorylated tau and β-amyloid substrates are present in olfactory areas, the molecular mechanisms associated with decreased smell function are not completely understood. We have applied mass spectrometry-based quantitative proteomics to probe additional molecular disturbances in po...

Parkinson disease is a multi-system neurodegenerative disease characterized by both motor and non-motor symptoms. Hyposmia is one of the early non-motor symptoms occurring in more than 90% of Parkinson disease cases, which can precede motor symptoms even several years. Up to now, the relationship between hyposmia and Parkinson disease remains elusive. Lack of proper animal models of hyposmia re...

CHARGE is a multiple congenital anomaly disorder and a common cause of pubertal defects, olfactory dysfunction, growth delays, deaf-blindness, balance disorders and congenital heart malformations. Mutations in CHD7, the gene encoding chromodomain helicase DNA binding protein 7, are present in 60-80% of individuals with the CHARGE syndrome. Mutations in CHD7 have also been reported in the Kallma...

Chemosensory (gustatory and olfactory) dysfunction contributes to obesity, but the association between body mass index (BMI) chemosensory are inconsistently reported. The present study included 4,390 subjects at a Smell Taste Clinic. Results suggested that both obesity class II group (BMI ≥ 35) underweight < 18.5) exhibited impaired taste function compared with normal weight (p .05). Comparing ...