نتایج جستجو برای: oligoclonal bands
تعداد نتایج: 49577 فیلتر نتایج به سال:
The majority of patients with multiple sclerosis have an abnormality of their spinal fluid immunoglobulins. This alteration is manifested as patterns of diffuse protein bands in the gamma globulin region following electrophoresis. This pattern has been termed one of restricted heterogeneity, or an oligoclonal pattern. We have found changes in the banding pattern of some patients studied longitu...
We report on a patient who presented with an inflammatory arthropathy clinically, though without a raised erythrocyte sedimentation rate, and in whom investigation subsequently showed erosive amyloidosis with an oligoclonal band. There was no evidence of rheumatoid disease and she has not developed any haematological malignancy. The only other case reported in the literature had an elevated ery...
OBJECTIVE To determine to what extent oligoclonal band (OCB) specificities are clonally interrelated and to what degree they are associated with corresponding B-cell responses in the peripheral blood (PB) of multiple sclerosis (MS) patients. METHODS Mass-spectrometric proteomic analysis of isoelectric focused (IEF) cerebrospinal fluid (CSF) immunoglobulin G (IgG) was used in combination with ...
Introduction Myelin-oligodendrocyte glycoprotein antibody (MOG)–associated disorder (MOGAD) is a recently identified immune-mediated inflammatory of the central nervous system (CNS). The significance oligoclonal bands (OCBs) not fully elucidated. This study investigated clinical differences between patients with MOGAD who tested positive or negative for OCBs. Methods was conducted on 23 MOG-IgG...
OBJECTIVE to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients. METHODS We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Final...
Background IgG concentrations in cerebrospinal fluid generally range from 20 to 45 mg/L. In multiple sclerosis immune reactions lead to intrathecal synthesis of specific IgGs that can be detected in biological fluid samples both quantitatively and qualitatively by isoelectric focusing of supplementary oligoclonal IgG bands. Method A simple tool, using the MATLAB application, to facilitate and...
Multiple sclerosis (MS) is difficult to diagnose using clinical evidence alone, especially early in the course of the disease. Yet, the importance of early detection is increasing because immunomodulatory therapy is believed to be most beneficial early in the disease process.1 MS is first suspected when recurrent clinical symptoms point to local destruction of myelin in at least 2 anatomic loca...
Klíčová slova oligoklonální pásy – mozkomíšní mok – IgG index – roztroušená skleróza Abstract Objective: The aim of this study was to assess the correlation between IgG index values and the number of the oligoclonal IgG bands (OCB) in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). Material and Methods: The set of 150 patients consisted of 41 males and 109 females (aged ...
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