نتایج جستجو برای: omalizumab
تعداد نتایج: 1422 فیلتر نتایج به سال:
BACKGROUND Bronchial thermoplasty (BT) is a recently developed treatment for patients with moderate-to-severe asthma. A few studies have suggested the clinical efficacy of this intervention. However, no study has evaluated the cost-effectiveness of BT compared to other alternative treatments for moderate-to-severe allergic asthma, which currently include omalizumab and standard therapy. OBJEC...
BACKGROUND In patients with asthma, particularly severe asthma, poor adherence to inhaled drugs negatively affects the achievement of disease control. A better adherence rate is expected in the case of injected drugs, such as omalizumab, as they are administered only in a hospital setting. However, adherence to omalizumab has never been systematically investigated. The aim of this study was to ...
The last few decades have seen a rise in the prevalence of allergic diseases, including asthma and allergic rhinitis. The prevalence asthma is estimated to be around 300 million globally and around 35% in Europe and Australasia and 60 million people in the United States are affected by rhinitis. In India prevalence asthma is estimated to be around 2.38% and 20% to 26% people suffer from allergi...
Bronchial asthma is characterised by high levels of immunoglobulin E (IgE) and overproduction of pro-inflammatory cytokines, including interleukins IL-4, IL-13 and IL-5 needed for, amongst other things, the production of IgE and the differentiation, maturation, migration and survival of eosinophils. Eosinophils are one of the most important cells in allergic inflammation. Their presence in tiss...
AIM To compare the efficacy ofprednisolone, montelukast, and omalizumab in reducing allergic symptoms and inflammation at tissue level in an experimental allergic rhinitis model. MATERIALS AND METHODS Forty Sprague Dawley rats were randomized into 5 groups as naive (NS/NC), sensitized/challenged (S/C) by subcutaneous ovalbumin antigen injection, and montelukast-, prednisolone-, and omalizumab...
An estimated two-thirds of asthma is allergic and .50% of severe asthma has an allergic component. An increased immunoglobulin (Ig)E production in response to environmental allergens (atopy) is the strongest detectable predisposing factor for the development of asthma, particularly when sensitisation occurs early in life. IgE binds to high-affinity receptors (FceRI) on effector cells, such as m...
PSS3 CoSt-EffECtivEnESS of omalizumab in ChroniC idioPathiC urtiCaria rEfraCtory to h1-antihiStaminES in turkEy Tatar M.1, Sezen S.2, Senturk A.3, Balp M.M.4, Saylan M.2, Keskinaslan A.2 1Hacettepe University, Ankara, Turkey, 2Novartis Pharma, Istanbul, Turkey, 3Polar Polar Health Economics & Policy, Ankara, Turkey, 4Novartis Pharma AG, Basel, Switzerland Objectives: Omalizumab is a humanised a...
ASTERIA I was a 40-week, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of subcutaneous omalizumab as add-on therapy for 24 weeks in patients with chronic idiopathic urticaria/spontaneous urticaria (CIU/CSU) who remained symptomatic despite H1 antihistamine treatment at licensed doses. Patients aged 12-75 years with CIU/CSU who remained symptomatic despit...
the rapid decrease in free serum IgE levels was noticed [3, 4] . However, the impact of omalizumab on changes in allergen-specific IgE levels has so far not been investigated. In a recent issue of the International Archives of Allergy and Immunology , Mizuma et al. [5] were the first to report changes not only in the levels of total IgE but also of allergen-specific IgE. The authors retrospecti...
Background Omalizumab is a recombinant monoclonal anti-immunoglobulin (Ig)E antibody (Ab), approved for treatment of severe asthma. The mechanisms by which is effective in asthma control are not yet fully understood but is known that it has an anti-inflammatory effect conducting to important clinical benefits. Urine sample collection is the least invasive form for biofluid sampling. The analysi...
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