نتایج جستجو برای: oncolysis
تعداد نتایج: 455 فیلتر نتایج به سال:
Cancer therapy remains a challenge due to toxicity limitations of chemotherapy and radiation therapy. Oncolytic viruses that selectively replicate and destroy cancer cells are of increasing interest. In addition to direct cell lysis, these vectors stimulate an anti-tumor immune response. A key regulator of tumor immunity is the tumor-associated macrophage population. Macrophages can either supp...
Intravenous injections of suspensions of spores of Cl. butyricum (Strain M-55) pro duced a more or less extensive lysis of tumor tissue. A number of other strains of nonpathogenic Clostridia did not show substantially improved results. In general, strains which were able to ferment carbohydrate performed equally well, whereas pri marily proteolytic strains gave inferior results. Combination of ...
Oncolytic herpes simplex virus-1 (oHSV) vectors selectively replicate in tumor cells, where they kill through oncolysis while sparing normal cells. One of the drawbacks of oHSV vectors is their limited replication and spread to neighboring cancer cells. Here, we report the outcome of a high-throughput chemical library screen to identify small-molecule compounds that augment the replication of o...
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