The aim of this study was to develop an extended-release tablet formulation using a new in situ cross-linking method. The effects of polyvalent cations on theophylline release from tablets made with the polyanionic polymers sodium alginate and sodium carboxymethylcellulose, were investigated. Different miliequivalents of the di and tri-valent cation, Ca2+ and Al3+, were added to tablet form...

 ABSTRACT Background: As any delay in the onset of milk production and ejection in the first few days after delivery can cause breast-feeding failure, this study has been done to determine factors that may affect the onset time of lactation in vaginal and cesarean section deliveries with and without labor pain (elective). Methods: 300 partUJient mothers selected from two private and university ...

extended-release matrix tablets of diltiazem hydrochloride (dtz) were prepared using waxy materials alone or in combination with kollidon sr. matrix waxy materials were carnauba wax (cw), bees wax (bw), cetyl alcohol (ca) and glyceryl monostearate (gms). dissolution studies were carried out by using a six stations usp xxii type 1 apparatus. the in vitro drug release study was done in 1000 ml ph...

Perthes' disease (Legg-Calvé-Perthes' disease) is relatively common in childhood, affecting 0.8/100.000 children. Late onset Perthes' disease, older than 8 years of age, constitutes about 20% of cases and is known for its aggressive course and poor outcome with chronic hip pain and stiffness. Although containment of the head in the acetabulum is the usual treatment for early cases, its results ...

A sustained-release tablet formulation should ideally have a proper release profile insensitive to moderate changes in tablet hardness that is usually encountered in manufacturing. In this study, matrix aspirin (acetylsalicylic acid) tablets with ethylcellulose (EC), Eudragit RS100 (RS), and Eudragit S100 (S) were prepared by direct compression. The release behaviors were then studied in two co...

Two experiments were performed to determine the effectiveness of different progestogens contained in intravaginal devices, different doses of eCG and subsequent hCG treatment on the reproductive performance of estrus-induced mature Lori ewes. In the first experiment, 88 ewes were allocated into two groups, and were treated with either fluorogestone acetate (FGA) sponges or Controlled Internal D...

The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of a highly water/soluble drug, salbutamol sulphate by (water in oil) in oil emulsion technique using ethyl cellulose as the retardant material. Various processing and formulation parameters such as drug/polymer ratio, stirring speed, volume of processing medium were optimized to maximize the e...