Reperfusion after brief, reversible myocardial ischemia is associated with prolonged depression of contractile function (myocardial "stunning"); however, the effect on coronary vascular function has not been defined. Thus, open-chest dogs (n = 14) underwent a 15-minute left anterior descending coronary artery (LAD) occlusion followed by reflow. Four hours after reperfusion, regional myocardial ...

Although previous studies suggested that the protection of late preconditioning (PC) against myocardial stunning is mediated by nitric oxide (NO), direct evidence that exogenous administration of NO attenuates myocardial stunning is lacking. Furthermore, although exogenous NO administration was shown to elicit a late PC phase, it is unknown whether NO donors also induce an early PC phase. There...

We have recently demonstrated the benefits of glucagon-like peptide-1 (GLP-1) in enhancing regional and global myocardial function after reperfusion in the clinical setting of acute myocardial infarction. We hypothesized that GLP-1 facilitates recovery from myocardial stunning after an ischemic event. To investigate this, we administered GLP-1 (1.5 pmol/kg/min) to six dogs undergoing 10-min occ...

Catecholamine-induced cardiomyopathy due to chronic excess of endogenous catecholamines has been recognized for decades as a clinical phenomenon. In contrast, reports of myocardial dysfunction due to acute iatrogenic overdose are rare. A 35-year-old woman whose cervix uteri was inadvertently injected with 8 mg of epinephrine developed myocardial stunning that was characterized by severe hemodyn...

The warm up phenomenon, first described more that 50 years ago in patients with effort angina, refers to the improved performance exhibited by more than half of all patients with coronary artery disease following their first exercise test. There are several potential causes of the warm up phenomenon including: (1) an improvement in oxygen supply, which, in turn, may be caused by stenosis dilati...

Brief periods of ischemia not only cause a long lasting (hours to days) myocardial contractile dysfunction (stunning) but also increase the tolerance for irreversible damage during a subsequent ischemic episode, a phenomenon called ischemic preconditioning.1J Heat-shock proteins, in particular HSP-70, have been postulated in myocardial protection against irreversible damage due to i~chemia .~ I...

specific (tsubo-type) left ventriculographic configuration due to multivessel spasm. In: Kodama K, Haze K, Hori M, editors. Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure [in Japanese]. Tokyo: Kagakuhyouronsya, 1990:56–64. 3. Dote K, Sato H, Tateishi H, et al. Myocardial stunning due to simultaneous multivessel spasms: a review of 5 cases [in Japanese with English abstract...

Ischemic preconditioning (IP) was originally defined as the enhancement of myocardial tolerance against infarction induced by a brief sublethal episode of ischemia in experimental animals (1,2). Subsequently, the concept of IP was expanded and currently includes protection against myocardial stunning, arrhythmia, and vascular dysfunction after ischemia/reperfusion injury (3–6). Results of clini...

AIMS Stress urinary incontinence (SUI) impacts many women. Treatment is primarily surgical. Post-operative morbidity considerably affects individuals and the health care system. Our objective is to describe complications following surgery for SUI and how they affect resource utilization. METHODS Utilizing the Nationwide Inpatient Sample (a nationally representative dataset), 147,473 patients ...