BACKGROUND Serious health problems and socioeconomic consequences of the illicit use of opiates have been proved in both developed and developing societies. OBJECTIVES We aimed to evaluate" The effects of opiate addiction through different administration routes on pulmonary inflammation and its severity." MATERIALS AND METHODS Our experiments were performed on eighteen adult male Syrian gol...

The aim of the present study was to find out the influence of psychopathology on abstinence from opiate addiction. A group of 54 opiate addicts with psychopathology was compared with another group of 55 opiate addicts without psychopathology. Both the groups were detoxified and followed up for a period of 12 months.Common psychopathology in opiate addicts consisted of psychopathic personality d...

HIV epidemic continues to be a severe public health problem and concern within USA and across the globe with about 33 million people infected with HIV. The frequency of drug abuse among HIV infected patients is rapidly increasing and is another major issue since injection drug users are at a greater risk of developing HIV associated neurocognitive dysfunctions compared to non-drug users infecte...

OBJECTIVES We evaluated the effects of an individual intervention versus a network intervention on HIV-related injection and sexual risk behaviors among street-recruited opiate injection drug users in 5 Ukraine cities. METHODS Between 2004 and 2006, 722 opiate injection drug users were recruited to participate in interventions that were either individually based or based on a social network m...

background previous studies have proven the development of white matter hyperintensities (wmh) in methamphetamine and opioid users. opiates and methamphetamines (ma) are the most common addictive agents in iran. the adverse effects of drugs on the cns is of concern to specialists and researchers, and given that the neurotoxicity associated with methamphetamine is greater than opioids, it is hyp...

An analog of human beta-endorphine with omission of four residues at positions 11, 14, 20, and 22 has been synthesized. This analog and other synthetic analogs with deletion of a single amino acid at position 2, 5, 6, 10, 11, 12, 13, 15, or 22 have been assayed for analgesic potency, ileal opiate activity,opiate receptor-binding activity, andimmunoreactivity. Results show that deletion of a sin...

BACKGROUND Candidate genes of the dopaminergic system have been reported as key elements in shaping human temperament. Catechol-O-methyltransferase (COMT) plays a vital role in dopamine inactivation, and the Val(158)Met single nucleotide polymorphism (rs4680) in its gene has been recently associated with the Novelty Seeking (NS) temperament scale of the Temperament and Character Inventory in st...

Centres for the treatment of drug abusers are often integrated with regional psychiatric hospitals and are the focus of the British response to opiate addiction. Little is known, however, about the use made of these services by drug users in the community or about the success of these services. This study examined the use made of one centre offering a detoxification service by a cohort of 183 h...

This report describes effective prolonged opiate blockade by subcutaneous depotnaltrexone (d-NTX) preparation. The d-NTX is a 1000 mg pellet inserted at opiate detoxification. The assay of effective opiate blockade was direct opiate challenge. Fifteen challenges were performed. Opiate challenges occurred from 21 to 70 days after d-NTX implantation (mean 40.9 days). All patients were refractory ...