Alcohol addiction is one of the most common and devastating diseases in the world. Given the tremendous heterogeneity of alcohol-addicted individuals, it is unlikely that one medication will help nearly all patients. Thus, there is a clear need to develop predictors of response to existing medications. Naltrexone is a μ-opioid receptor antagonist, which has been approved in the United States fo...

Links: [1] https://www.buppractice.com/node/103 [2] http://dpt.samhsa.gov/pdf/HepC_draft_monograph_5-8-2006.pdf [3] https://www.buppractice.com/taxonomy/term/28 [4] https://www.buppractice.com/taxonomy/term/116 [5] https://www.buppractice.com/taxonomy/term/50 [6] https://www.buppractice.com/taxonomy/term/52 [7] https://www.buppractice.com/taxonomy/term/61 [8] https://www.buppractice.com/taxonom...

BACKGROUND Failure in treating opioid dependence is costly to the patient, the employer, managed care organizations, and the overall health care system. Opioid dependent patients tend to be less productive at work and in society and utilize a great many health care resources. Optimizing outcomes is essential. OBJECTIVE To introduce the benefit of integrated strategies and patient support in t...

The value of chronic opioid therapy (COT) for chronic non-cancer pain (CNCP) patients is determined by a balance of poorly understood benefits and harms. Traditionally, this balance has been framed as the potential for improved pain control versus risks of iatrogenic addiction, drug diversion, and aberrant drug-related behaviors. These potential harms are typically defined from the providers' p...

background addiction is a community problem, which has a negative effect on mental health and huge burden on society. previous studies clarify the role of substance abuser attitude on addiction.this study aimed to evaluate the effect of psycho education on attitude to drug addiction in patients with opioid dependency. material and methods total 40 patients (age18-45 years old), who have been re...

The rewarding properties of some abused drugs are thought to reside in their ability to increase striatal dopamine levels. Similar increases have been shown in response to expectation of a positive drug effect. The actions of opioid drugs on striatal dopamine release are less well characterized. We examined whether heroin and the expectation of heroin reward increases striatal dopamine levels i...

INTRODUCTION Opioid abuse has reached epidemic levels. Evidence-based treatments such as buprenorphine maintenance therapy (BMT) remain underutilized. Offering BMT in primary care settings has the potential to reduce overall costs of care, decrease medical morbidity associated with opioid dependence, and improve treatment outcomes. However, access to BMT, especially in rural areas, remains limi...

without loss of opioid analgesia. Clin Pharmacol Ther 2010; 87:204–11 5. Dahan A, Aarts L, smith TW: Incidence, reversal, and prevention of opioid-induced respiratory depression. ANEsThEsIoLogy 2010; 112:226–38 6. Boom M, Niesters M, sarton E, Aarts L, smith TW, Dahan A: Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des 2012; 18:5994– 6004 7. okie s: A floo...

Chemical coping is a working definition that describes patients' intake of opioids on a scale that spans the range between normal nonaddictive opioid use for pain all the way to opioid addiction. Most patients will fall somewhere between the two extremes in using opioid analgesics to cope with their psychological or spiritual distress. The degree to which patients use their medications in a mal...