The inability of mature CNS neurons to regenerate injured axons has been attributed to a loss of inherent growth potential of cells and to inhibitory signals associated with myelin and the glial scar. The present study investigated two complementary issues: (1) whether mature CNS neurons can be stimulated to alter their gene expression profile and switch into a strong growth state; and (2) whet...

Endoscopic imaging in tubular structures, such as the tracheobronchial tree, could benefit from imaging optics with an extended depth of focus (DOF) to accommodate the varying sizes of tubular structures across patients and along the tree within the same patient. Yet the extended DOF needs to be accomplished without sacrificing resolution while maintaining sufficient sensitivity and speed of im...

We aimed to examine the distribution of SEPT4, SEPT5, and SEPT8 in the human eye. For each septin, five to six normal human eyes were examined by immunohistochemical staining of paraffin sections using polyclonal antibodies against SEPT4, SEPT5, and SEPT8 and an avidin biotin complex immunodetection system. SEPT4 immunoreactivity (IR) was detected primarily in the epithelium of cornea, lens, an...

Vertebrate eye development begins at the gastrula stage, when a region known as the eye field acquires the capacity to generate retina and lens. Optx2, a homeobox gene of the sine oculis-Six family, is selectively expressed in this early eye field and later in the lens placode and optic vesicle. The distal and ventral portion of the optic vesicle are fated to become the retina and optic nerve, ...

PURPOSE To evaluate the clinical outcomes of intraocular lens (IOL) exchange in patients with an opacified ACRL-C160 intraocular lens (IOL) using an optic-only removal technique. SETTING Department of Ophthalmology, Soonchunhyang University Hospital, Seoul, Korea. METHODS The study comprised eyes with previous phacoemulsification and implantation of a single-piece hydrophilic acrylic IOL in...

PURPOSE To examine the relationship between intraocular pressure (IOP), anthropomorphic, demographic, socioeconomic, systemic, and ocular factors and glaucomatous optic neuropathy (GON) in Chinese people. METHODS Chinese people (n = 2000), aged 40 to 79 years, were selected from the Singapore electoral register. Of the 1717 considered eligible for examination, 1232 participated, representing ...

A knowledge of the optic disc size may be of value when assessing the glaucoma suspect. The vertical diameter of the optic disc was measured using a Zeiss four mirror gonioscope and a 900 Haag-Streit slit-lamp in one eye of 39 patients, 32 with refractive errors within 3 dioptres of emmetropia. The disc was measured by projecting a slit beam of known height onto the image of the disc. A magnifi...

An in vivo exposure to 197  W/cm 2 1090-nm infrared radiation (IRR) requires a minimum 8 s for cataract induction. The present study aims to determine the ocular temperature evolution and the associated heat flow at the same exposure conditions. Two groups of 12 rats were unilaterally exposed within the dilated pupil with a close to collimated beam between lens and retina. Temperature was recor...