Sequencing by hybridization (SBH) is a promising alternative approach to DNA sequencing and mutation detection. Analysis of the resolving power of SBH involves rather difficult combinatorial and probabilistic problems, and sometimes computer simulation is the only way to estimate the parameters and limitations of SBH experiments. This paper describes a software package, DNA-SPECTRUM, which allo...

Efficient and versatile photon-number resolving detectors are critical to the development of future communication systems. The quantum-dot, optically-gated, field-effect transistor (QDOGFET) is one such detector. Utilizing quantum dots (QDs), tiny islands semiconductor, imbedded in a transistor, QDOGFETs have been shown exhibit single-photon sensitivity photon-number-resolving (PNR) capabilitie...

The resolving power of a spectrometer in the infrared is limited by the rate at which energy passes through the exit slit of the spectrometer. Calculation of the energy available for activating a thermocouple, under condition that the exit slit embrace the same frequency range Av of spectrum at all times, gives information on the attainable resolving power at various wave-lengths and with vario...

There is a pressing need for continuous purification of products of synthesis conducted in continuous-flow microreactors. An existing technique, micro free-flow electrophoresis (microFFE), could fulfill this niche if its resolving power for similar molecules was improved. MicroFFE continuously separates ions in the hydrodynamic flow by an electric field orthogonal to the flow. Here, we prove th...

in future high-speed self-routing photonic networks based on all-optical time division multiplexing (otdm) it is highly desirable to carry out packet switching, clock recovery and demultplexing in the optical domain in order to avoid the bottleneck due to the optoelectronics conversion. in this paper we propose a self-routing otdm node structure composed of an all-optical router and demultiplex...

ArcLight is a genetically encoded fluorescent voltage sensor using the voltage-sensing domain of the voltage-sensing phosphatase from Ciona intestinalis that gives a large but slow-responding optical signal in response to changes in membrane potential (Jin et al., 2012). Fluorescent voltage sensors using the voltage-sensing domain from other species give faster yet weaker optical signals (Baker...

We developed a new ultramicroscopy design equipped with modified optics to achieve 3D-vizualizations of specimens with μm-resolution. The optical unit consists of elements with complex surface structures to create an ultra-thin light sheet. Diffraction and other unwanted optical effects are minimized, while the laser energy is used more efficiently. This enables us to obtain marked enhancements...