clinical applications of mesenchymal stem cells (mscs) rely on their capacity to home and engraft in the appropriate target tissues for a long time. homing and engraftment capacity of these stem cells depend on the expression of chemokines and their receptors. ex vivo expanded mscs exhibit homing potential when grafted to injury tissue but their homing efficiency has been observed very poor bec...

thalassemia is an autosomal recessive disorder associated with defective synthesis of the α- or β-chain of hemoglobin. for β-thalassemia major patients, therapeutic options are either monthly red cell transfusions and chelation therapy or allogeneic stem cell transplant. stem cell transplant is the only curative approach and success is inversely correlated with the degree of iron overload and h...

trying to use embryonic stem cells about 20 years ago, working with animals,  especially rats began. during these years , many experiments in mouse embryonic stem cells to transform into a variety of cells and transplanting them were led to remarkable success . in the next issue of human stem cells were considered successful until finally in 1998 the first report was published in the proliferat...

a b s t r a c t introduction: even today there is no effective drug therapy to prevent neuronal loss after brain stroke. in the present study we studied the effect of mitochondrial katp channel regulators on neuronal ultrastructure after ischemia reperfusion in the rat. materials & methods: rats temporarily subjected to four vessels occlusion for 15 minutes followed by 24 hours reperfusion with...

Annotation. The work aims to conduct a biophysical assessment of the charge state buccal epithelium cells (BEC), microcirculatory channel oral mucosa and fluid in patients with erosive-ulcerative form lichen planus. problem is relevant due increasing number planus patients, uncertain etiology disease, ongoing struggle find treatment solutions. 11 aged 50-60 years (erosive-ulcerative form) were ...

stem cells are naïve or master cells. this means they can transform into special 200 cell types as needed by body, and each of these cells has just one function. stem cells are found in many parts of the human body, although some sources have richer concentrations than others. some excellent sources of stem cells, such as bone marrow, peripheral blood, cord blood, other tissue stem cells and hu...

recently, cell therapy has sparked a revolution in ischemic heart disease that will in the future help clinicians to cure patients. earlier investigations in animal models and clinical trials have suggested that positive paracrine effects such as neoangiogenesis and anti-apoptotic can improve myocardial function. in this regard the royan cell therapy center designed a few trials in collaboratio...

introduction:first, definition the stem cell refers to those cells that are still not clear and are not equipped for a particular task. these cells have proliferative properties and  ability to differentiate into other types of cells have become. this characteristic of stem cells to self-directed has absorbed professional opinion that extensive research is done in this regard. nowadays, stem ce...

liver failure, in an acute or chronic form, is a growing health problem ranking as one of the leading causes of death worldwide. inborn errors of metabolism characterized by defects in hepatic enzymes or other proteins with metabolic functions, such as receptors or transporters accompanied with environmental factors involve etiology and presentation of liver failure. currently, the only establi...

Thirteen repetitions of a cross-channel transect in the Khuran Channel within the Strait of Hormuz allowed the description of the mean flow and semidiurnal tidal properties of a north-south transect. Water velocity profiles were obtained with a 614.4 kHz TRDI Work Horse Broadband ADCP along this 3.3 km long transect on 10 October 2014, the third day of secondary spring tide. The M2, M4 and M6 f...