lichen planus (lp) is a chronic inflammatory disease of probable immune-based etiology. the pathogenesis of lp is unclear, but apoptotic changes in epidermal (epithelial) cells have been reported. destruction of the basal cell layer is observed and many changes in cell proliferation, cell repair and cell death occur in the injured mucosal epithelium. the aim of this study was to evaluate and co...

Oral lichen planus (OLP) is a chronic inflammatory and immune-mediated disease that presents as bilateral, symmetrical oral lesions with three main clinical presentations: reticular, atrophic, erosive. It clinically characterized by pain, burning sensation, discomfort for sufferers. Currently OLP classified potentially malignant disorder. has been associated numerous systemic connotations such ...

Lichen planus (LP) is a chronic T-cell-mediated mucocutaneous inflammatory disease that targets stratified epithelia, including those lining the oral cavity. The intraoral variant of LP (OLP) is associated with interferon (IFN)-γ production by infiltrating T lymphocytes; however, the role of epithelial cells in the etiopathogenesis OLP is not completely understood. There is however a growing bo...

Introduction. Aberrations of the Akt/mTOR/pS6 pathway have been linked to various types of human cancer, including oral squamous cell carcinoma (OSCC). The purpose of this study was to evaluate the activation status of Akt, mTOR, and pS6 in oral lichen planus (OLP) in comparison with oral premalignant and malignant lesions and normal oral mucosa (NM). Materials and Methods. Immunohistochemistry...

oral lichen planus is a chronic inflammatory immune-mediated disease. icam-1 and vcam-1 are vascular adhesion molecules that their receptors are located on endothelial cells and leukocytes. the aim of this study is the immunohistochemical evaluation of vcam1 and icam1 in oral lichen planus and to compare these two markers with normal mucosa for evaluation of angiogenesis. this descriptive-analy...

Introduction: Oral lichen planus (OLP) is an autoimmune disease with uncertain etiopathogenecity and no definitive treatment. Considering the recurrent nature of OLP, finding an adjunctive treatment to minimize the risk of chronicity and recurrence of OLP and to decrease the adverse effects of corticosteroids can be promising. This study aimed to assess the efficacy of a mixture of hyaluronic a...

OBJECTIVES The aim of the present study was to analyze the main clinical and histopathological features of autoimmune diseases with oral manifestations such as oral lichen planus (OLP); mucous membrane pemphigoid (MMP); pemphigus vulgaris (PV) and erythema multiforme (EM). STUDY DESIGN Retrospective review of 5770 files from the Oral Pathology Laboratory of São José dos Campos Dental School, ...

background and aims. lichen planus is a relatively common mucocutaneous disease, with an unknown etiology. there is no complete cure for oral lichen planus (olp), but some drugs, including corticosteroids, retinoids, cyclosporine and antibiotics are commonly used for treatment of olp. the aim of the present study was to compare the effect of combination of triamcinolone and vitamin a mouthwash ...

Background: Oral Lichen Planus (OLP) is a chronic inflammatory disease affecting the oral mucosa in 0.5-2% of the world’s population. It is more common in women compared to men and the mean age at the onset of the lesion is the fourth decade. Objectives: The purpose of this study was to evaluate the presence of Helicobacter pylori (H. pylori) in Oral Lichen Planus and Oral Lichenoid Reaction. M...

OBJECTIVE Lichen planus and lichenoid lesions affecting the oral cavity show similar clinico-pathological features creating a diagnostic dilemma. Hence, the aim of the present study was to establish a clinical and histopathological correlation in the diagnosis of oral lichen planus, based on the modified WHO diagnostic criteria of oral lichen planus and oral lichenoid lesions proposed by Van de...