Male sexual behavior (MSB) is modulated by gonadal steroids, yet this relationship is highly variable across species and between individuals. A significant percentage (~30%) of B6D2F1 hybrid male mice demonstrate MSB after long-term orchidectomy (herein after referred to as "maters"), providing an opportunity to examine the mechanisms that underlie individual differences in steroidal regulation...

OBJECTIVE To examine purinergic signaling in human vas deferens. DESIGN To study contractile responses of the scrotal vas deferens. SETTING Research department of a university teaching hospital. PATIENT(S) Undergoing vasectomy or orchidectomy (aged 27-88 years, n = 14). INTERVENTION(S) Vasectomy or orchidectomy. MAIN OUTCOME MEASURE(S) Strips of vas deferens were suspended in an organ...

Preoperative intra-individual variation for determinations of prostate-specific antigen and prostatic acid phosphatase concentrations, 15-30% in 92 patients with benign prostatic hyperplasia, limits the diagnostic usefulness of both tumor markers. In benign prostatic hyperplasia (214 patients), concentrations of these tumor markers increased in the initial postoperative period. Prostatic acid p...

BMJ 1993;307:790-3 Mr K is a 59 year old man with a long history of persistent sexual abuse against children. His abusive behaviour began when he was at school and continued into his marriage. He abused his own children, and, despite many periods of imprisonment, he continued to abuse children each time he was released. His last period ofimprisonment was for 10 years. During that last period in...

Granulosa cell tumours are extremely rare and very few cases of adult type have been reported till date . can broadly classified into juvenile types. They known to occur more commonly occurs in females (in ovaries) than males testis) We here a case 39 year old man who was diagnosed with testicular granulose tumour no metastasis A High Inguinal radical Orchidectomy performed histology demonstrat...

the testicular torsion which is typically seen in prepuberty is very rare in the early neonatal period; prenatal diagnosis is difficult. herein, we report a five day-old male neonate with swelling and erythema of the right scrotum.  following doppler ultrasound suggestive of testicular torsion, surgical exploration was undertaken. there was gangrene of the right testis with discoloration and ne...

Clinical studies indicate that proton pump inhibitors (PPIs), used long-term in elderly patients, increase the risk of osteoporotic fractures, and decrease the anti-fracture efficacy of alendronate. The aim of the present study was to examine the effect of physical exercise on the anti-osteoporotic efficacy of alendronate administered concurrently with lansoprazole, a PPI, in male rats with and...

INTRODUCTION We report the case of a true hermaphrodite with testicular seminoma with resulting metastases to the inguinal lymph nodes eight months after radical orchidectomy. This is an unusual presentation of testicular cancer and, to the best of our knowledge, the first report of this kind in the literature. CASE PRESENTATION A 45-year-old Caucasian true hermaphrodite, raised as a male, de...

The treatment options available for the management of stage I seminoma consist of either a surveillance strategy or adjuvant therapy after orchidectomy. A systematic review was undertaken to identify the optimal management strategy. The MEDLINE and EMBASE databases, in addition to the American Society of Clinical Oncology Meeting Proceedings, were searched for the period 1981 to May 2007. Studi...

AIM OF THE STUDY To review management and outcomes in patients with stage I seminoma after orchidectomy. MATERIAL AND METHODS Between 1979 and 2004 a total 292 patients with stage I seminoma were treated with adjuvant chemotherapy or radiotherapy or were placed on surveillance. Median age at diagnosis was 36 years (range 20-69), with median follow-up 76.5 months (range 11-294). Of the patient...