We examined whether access to US-approved orphan drugs in Canada has changed between 1997 (when Canada chose not to adopt an orphan drug policy) and 2012 (when Canada reversed its policy decision). Specifically, we looked at two dimensions of access to US-approved orphan drugs in Canada: (1) regulatory access; and (2) temporal access. Whereas only 63% of US-approved orphan drugs were granted re...

We have identified a member of the steroid receptor superfamily and cloned it from human and rat hypothalamus, prostate, and testis cDNA libraries. The open reading frame between first ATG and terminator TGA can encode 615 (human) and 596 (rat) amino acids with calculated molecular mass of 67.3 (human) and 65.4 (rat) kDa. The amino acid sequence of this protein, called TR4 orphan receptor, is c...

The purpose of this study was to examine maternal and adolescent depression, maternal and teen sensation seeking, and maternal smoking, and their associations with adolescent smoking. Data were collected from a sample of 47 male and 66 female adolescents (ages 11-18 years) and their mothers from three different health clinics. The findings indicated that maternal sensation seeking was linked in...

As supported by ecological systems theory and the family stress model of economic hardship, socioeconomic status can directly be related to adolescent adjustment outcomes including selfregulation, academic performance, and substance use as well as be indirectly related to these outcomes through the mediator of parental monitoring. Data obtained from 220 adolescent (male = 55%, female = 45%, mea...

The aim of this study was to develop a typology of adolescent sex offenders based on object relations theory and Otto F. Kernberg's model of personality organizations (PO). A secondary objective was to compare the identified subtypes on offense characteristics as well as some psychological variables of adolescent sex offenders. Clinical files from 40 male adolescent sex offenders in treatment w...

This paper explores two orphaned girls' accounts of victimization and vulnerability to child sexual abuse in their family homes. Interviews with these girls revealed a trend neglect, adversity processes adultification which involved within According the data, participants are vulnerable they experience as routinely sexually abused by older male relatives non-related men boys inside homes – wher...

Purpose: This project aimed to test an IoT and AI based system that monitor students from home schools, during class hours school notify parents administrators about the irregularity observed their respective children.
 Methodology: In this project, secondary data was used retrieved school’s record of Wisdom School Musanze located in District. The main consider were sex whether male or fem...

Male adolescents’ sexual and reproductive health needs often go unmet in the primary care setting. This report discusses specific issues related tomale adolescents’ sexual and reproductive health care in the context of primary care, including pubertal and sexual development, sexual behavior, consequences of sexual behavior, and methods of preventing sexually transmitted infections (including HI...

There is strong consensus in the research literature that adolescent and adult men who report same-sex sexual orientations, identities, and behaviors are at higher risk for suicide. Recent studies of general adolescent suicide risk have identified developmental trajectories that peak during the teenage years. Because the adolescent years are characterized by the development and heightened aware...

BACKGROUND Orphan drugs are a growing issue of importance to European healthcare policy makers. The success of orphan drug legislation in Europe has resulted in an increasing number of licensed medicines for rare diseases, and many more yet unlicensed products have received orphan drug designation. Increasingly the concerns amongst policy makers relate to issues of patient access and affordabil...