Structure-toxicity relationships for a series of 75 azo and azo-anilide dyes and five diazonium salts were developed using Hydractinia echinata (H. echinata) as model species. In addition, based on these relationships, predictions for 58 other azo-dyes were made. The experimental results showed that the measured effectiveness Mlog(1/MRC50) does not depend on the number of azo groups or the ones...

A ruthenium complex formed from commercially available [Ru(p-cymene)Cl2]2 and 1,4-bis(diphenylphosphino)butane catalyzes the racemization of aromatic α-hydroxy ketones very efficiently at room temperature. The racemization is fully compatible with a kinetic resolution catalyzed by a lipase from Pseudomonas stutzeri. This is the first example of dynamic kinetic resolution of α-hydroxy ketones at...

Treatment of various aliphatic and aromatic aldoximes with the hypervalent iodine(iii) reagents (diacetoxyiodo)benzene (DIB) or Koser's reagent [hydroxy(tosyloxy)iodo]benzene (HTIB) gave, respectively, N-acetoxy or N-hydroxy amides in good yields rather than the expected nitrile oxide dimerised product oxadiazole-N-oxides reported to be formed with other oxidising and hypervalent iodine reagent...

The carcinogenicity of seven metabolites of the essential amino acid tryptophan and nine other nitrogen-containing aromatic compounds was studied by the individ ual suspension of these chemicals in cholesterol pellets and the surgical implantation of the pellets into the bladders of mice. Pellets consisting of the 8-methyl ether of xanthurenic acid, xanthurenic acid, 8-hydroxyquinaldic acid, 3-...

The unimolecular reactivities of a range of perbenzoate anions (X-C6H5CO3-), including the perbenzoate anion itself (X = H), nitroperbenzoates (X = para-, meta-, ortho-NO2), and methoxyperbenzoates (X = para-, meta-OCH3) were investigated in the gas phase by electrospray ionization tandem mass spectrometry. The collision-induced dissociation mass spectra of these compounds reveal product ions c...

gens in the neoplastic processes induced by these compounds. The fact that the aromatic aminoazo dyes are carcinogenic primarily in the liver and generally not at sites of local application (16) has suggested that the aminoazo dyes are likewise active through the formation of reactive metabolites. The structural similarity be tween the aminoazo dyes and the carcinogenic aromatic amines and amid...

gens in the neoplastic processes induced by these compounds. The fact that the aromatic aminoazo dyes are carcinogenic primarily in the liver and generally not at sites of local application (16) has suggested that the aminoazo dyes are likewise active through the formation of reactive metabolites. The structural similarity be tween the aminoazo dyes and the carcinogenic aromatic amines and amid...

The first aim of the present study was to evaluate which structural elements of the 2-methoxy-4-vinylphenol (MVP) molecule (1) are responsible for its observed activity as germination inhibitor in wheat seeds. To find its mode of action, a series of compounds with varying functional moieties and substitution patterns were prepared and evaluated for their inhibitory activity. This systematic com...

A total of 28 lapachol-related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine-resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method. Cytotoxicity against Hep G2A16 cell was determined by the MTT assay. All compounds disclosed higher in...