Osteoprotegerin (OPG) is a recently discovered protein related to the tumor necrosis factor receptor family. It has been shown to inhibit ovariectomy (ovx)-induced resorption in rats and increase bone mineral density in young mice. Tail suspension is a procedure that inhibits bone formation in maturing rodents. This study was designed to quantify OPG's effect on cortical bone formation. Fifty-f...

Notch receptors are determinants of cell fate decisions. To define the role of Notch in the adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD) under the control of the type I collagen promoter. First-generation transgenics were small and osteopenic. Bone histomorphometry revealed that NICD caused a decrease in bone volume, secondary to a reduction in...

background: thalassemia is the most common hereditary anemia and beta thalassemia major is its most severe form. endocrine abnormalities in thalassemia major are common disturbing complications that need prompt management. the purpose of this study was to determine the endocrine disorders and bone mineral density in patients with major -thalassemia in qazvin, iran. methods: in this cross- secti...

PURPOSE Steroids, inhaled and systemic, are used to treat airway inflammation in patients with asthma; however, steroids are recognized to cause a number of side effects, including osteoporosis. We evaluated the prevalence of osteopenia/osteoporosis in patients with moderate-severe asthma managed through the Edmonton Regional Severe Asthma Centre. METHODS We performed a retrospective chart re...

BACKGROUND/AIMS Liver cirrhosis is associated with osteopenia and also with low levels of IGF-I. This hormone has been reported to stimulate bone formation in states of undernutrition and low bone turnover. Our aims were to evaluate whether osteopenia develops in male Wistar rats with CCl4-induced cirrhosis and whether IGF-I is effective in the restoration of bone mass in these animals. METHO...

A Multidisciplinary National Panel of Experts in the management of Menopause and Postmenopausal Osteoporosis was created to determine the specific positioning of Bazedoxifene acetate (BZA), a third-generation selective estrogen receptor modulator (SERM), in the field of available therapeutic options in prevention and treatment of postmenopausal osteoporosis.There are various therapeutic options...

Background: Many factors can cause changes in bone mass density (BMD) women with postmenopausal osteopenia. Aim: Determine associated BMD osteopenia the most influential risk within 1 year.Methods: Survey was conducted on 38 patients who were included inclusion criteria a cross-sectional study analysis and had data for last 2 years, body index, interviews physical activity, age of menopause, du...

There is substantial data supporting the importance of both endogenous and exogenous estrogen in maintaining reproductive health preventing chronic disease, androgens women's are rarely discussed. This one first researches to investigate correlates blood testosterone concentrations women with osteopenia, anticipation growing interest role health. A 65 volunteer were enrolled current study, they...

Aim: Osteoporosis and osteopenia are common in Saudi Arabia the burden of management an aging population will increase coming decades. The study aimed to describe prevalence osteoporosis among patients more than 50 years old, identify risk factors these conditions, as well adherence guideline for treating a government hospital Al-Kharj, Arabia. Methods: This is retrospective case–control perfor...

The present study aimed at investigating the weak cation magnetic separation technology and matrixassisted laser desorption ionization-time of flight-mass spectrometry (MALDI-TOF-MS) in screening serum protein markers of osteopenia from 10 perimenopausal women with normal bone mass and 10 perimenopausal women without osteopenia as control group, to find a new method for screening biomarkers and...