There are ~660,000 deaths from severe malaria each year. Intravenous artesunate (i.v. ARS) is the first-line treatment in adults and children. To optimize the dosing regimen of i.v. ARS, the largest pooled population pharmacokinetic study to date of the active metabolite dihydroartemisinin (DHA) was performed. The pooled dataset consisted of 71 adults and 195 children with severe malaria, with ...

The Cambridge Structural Database (CSD) contains a complete record of all published organic and metal-organic small-molecule crystal structures. The database has been in operation for over 50 years and continues to be the primary means of sharing structural chemistry data and knowledge across disciplines. As well as structures that are made public to support scientific articles, it includes man...

In a previous study, we have found that the speed of stopping a response is delayed when response readiness is reduced by cuing the probability of no-go trials [Acta Psychol. 111 (2002) 155]. Other investigators observed that responses are more forceful when the probability to respond is low than when it is high (e.g. [Quart. J. Exp. Psychol. A 50 (1997) 405]). In this study, the hypothesis was...

BACKGROUND A number of cognitive deficits are associated with dyslexia. However, only a limited amount of research has been performed exploring a putative link between dyslexia and substance use. As substance use is thought to involve a cognitive component, it is possible that the pattern of substance use would be different for dyslexic participants, when compared to nondyslexic controls. Durin...

Elevated rates of substance use (alcohol, tobacco, cannabis) have been reported in people at clinical high risk (CHR) of developing psychosis and there is some evidence that substance use may be higher in those who convert to a psychosis compared to non-converters. However little is known about the predictive value of substance use on risk of conversion to psychosis in those at CHR of psychosis...

The paper presents a software architecture aiming to improve accessibility to information in specialized texts, with focus on medical texts. This software also addresses other problems related to text accessibility such as vision problems and language problems. It allows text input in any media format (text, image, sound) and outputs the text as digital text or sound, permitting the user to sca...

As with every other organism whose genome has been sequenced (Hinton, 1997; Bork et al., 1998), a chief finding in plants (Bevan et al., 1999; Somerville and Somerville, 1999) is the presence of a vast number of genes (many with no relatives in the databases) whose existence, let alone function, had previously gone unrecorded. The importance of finding the function of these genes has led to wha...

We study the rapid X-ray time variability in all public data available from the Rossi X-ray Timing Explorer's Proportional Counter Array on the atoll source 4U 1820–30 in the low-luminosity island state. A total of ∼ 46 ks of data were used. We compare the frequencies of the variability components of 4U 1820–30 with those in other atolls sources. These frequencies were previously found to follo...

OBJECTIVE Adolescent substance use is an area of concern because early substance use is associated with a higher risk of adverse outcomes. Parenting style, defined as the general style of parenting, as well as substance-specific parenting practices may influence children's substance use behaviour. The present study aims to probe the impact of parenting style on adolescent substance use. METHO...

Various subsets of the tracial state space of a unital C∗-algebra are studied. The largest of these subsets has a natural interpretation as the space of invariant means. II1-factor representations of a class of C∗-algebras considered by Sorin Popa are also studied. These algebras are shown to have an unexpected variety of II1-factor representations. In addition to developing some general theory...