OBJECTIVE The purpose of this study was to examine the anti-ototoxic impact of Ginkgo biloba extract and lycopene on the model of cisplatin-induced ototoxicity in rats. MATERIALS AND METHODS Thirty-two Wistar albino rats were examined with the distortion product otoacoustic emission (DPOAE) test (MADSEN Capella2 ; GN Otometrics, ICS Medical, Chicago USA), and they were randomly divided into f...

The sensory hair cells of the inner ear are exquisitely sensitive to ototoxic insults. Loss of hair cells after exposure to ototoxic agents causes hearing loss. Chemotherapeutic agents such as cisplatin causes hair cell loss. Cisplatin forms DNA mono-adducts as well as intra- and inter-strand DNA crosslinks. DNA cisplatin adducts are repaired through the DNA damage response. The decision betwee...

Cisplatin (CDDP) is a highly effective chemotherapeutic agent but with significant ototoxic side effects. Apoptosis is an important mechanism of cochlear hair cell loss following exposure to an ototoxic level of CDDP. This study examines intracellular pathways involved in hair cell death induced by CDDP exposure in vivo to develop effective therapeutic strategies to protect the auditory recepto...

Introduction: Sensorineural hearing loss (SNHL) is a probable complication of coronary artery bypass graft (CABG) Surgery, that may be due to embolism, perfusion failure and consumption of ototoxic drugs. Since the incidence of SNHL after CABG is different according to the various reports, the present study was designed to study hearing threshold change after CABG surgery. Method: In this cross...

Hearing loss caused by cochlear hair cell loss is the most common process afflicting the hearing impaired. Recent studies in the avian cochlea following ototoxic drug and noise damage have demonstrated a remarkable capacity for anatomical and functional recovery. Hair cell regeneration has been shown to play a major role in this recovery process. Future studies may one day make hair cell regene...

This was a cross-sectional study based on surveys conducted in 1997, 1999, 2005, 2007 and 2009 by Statistics Sweden (SCB) representing the Swedish work force. Data concerning working environment was collected by phone interview and questionnaire. The response rate for the phone interview was 88% (12546 employed persons) and for questionnaire there was a 69% response rate (9798 employed persons)...

Gentamicin sulphate is used clinically to produce vestibular organ damage in patients with intractable vertigo. The drug is given locally by middle ear instillation. In humans, gentamicin appears to have a more toxic effect on the vestibular parts of the inner ear than on the cochlea. However, cochlear effects are not insignificant and to further explore the utility of monitoring vestibular and...

Forouzesh and colleagues recently reported an increase in vancomycin ototoxicity in parallel with the increasing use of higher vancomycin doses (4). The report suggests an overall incidence of vancomycin-induced ototoxicity of 12%, doubling historic estimates (3). This is a surprisingly high estimate for a drug that many experts do not consider to be ototoxic (5, 6). The authors have outlined s...

Contemporary research efforts have provided new insight into the processes underlying common hearing impairments include aging, genetic defects, and environmental stress such as excessive noise (NIHL) or chemotherapeutic drugs. The primary cause of hearing impairment involves the death of sensory cells (hair cells) and neurons in the cochlea which are irreplaceable in mammmals. Rehabilitative m...