in the analysis of spatial point patterns, complete spatial randomness (csr) hypothesis,which is a restriction of a homogenous poisson process to study region a, operates as a dividinghypothesis between “regular” and “aggregated” patterns. meanwhile, many alternatives to csr inaggregated patterns are extensions of homogenous poisson processes themselves. therefore, when thecsr hypothesis is rej...

A comprehensive effort was undertaken to identify articles demonstrating chemical hormesis. Nearly 4000 potentially relevant articles were retrieved from preliminary computer database searches by using various key word descriptors and extensive cross-referencing. A priori evaluation criteria were established including study design features (e.g., number of doses, dose range), statistical analys...

The psychiatric category of addiction has recently been broadened to include new behaviors. This has prompted critical discussion about the value of a concept that covers so many different substances and activities. Many of the debates surrounding the notion of addiction stem from different views concerning what kind of a thing addiction fundamentally is. In this essay, we put forward an accoun...

We present a novel computational model that describes action perception as an active inferential process that combines motor prediction (the reuse of our own motor system to predict perceived movements) and hypothesis testing (the use of eye movements to disambiguate amongst hypotheses). The system uses a generative model of how (arm and hand) actions are performed to generate hypothesis-specif...

Sequence alignment depends on the scoring function that defines similarity between pairs of letters. For local alignment, the computational algorithm searches for the most similar segments in the sequences according to the scoring function. The choice of this scoring function is important for correctly detecting segments of interest. We formulate sequence alignment as a hypothesis testing probl...

Roy’s largest root is a common test in multivariate analysis of variance (MANOVA), with applications in several other problems, such as signal detection in noise. In this paper, assuming multivariate Gaussian observations, we derive a simple yet accurate approximation for the distribution of Roy’s largest root test, in the extreme case of concentrated non-centrality, where the signal or differe...