We studied the role of miRNA-200 family members in cellular sensitivity to paclitaxel and carboplatin, using two ovarian cancer cell lines, OVCAR-3 and MES-OV, and their paclitaxel resistant variants OVCAR-3/TP and MES-OV/TP. Both resistant variants display a strong epithelial-mesenchymal transition (EMT) phenotype, with marked decreases in expression of miR-200c and miR-141 in OVCAR-3/TP, and ...

Liposomal anticancer agents can effectively deliver drugs to tumor lesions, but their therapeutic effects are enhanced in only limited number of patients. Appropriate biomarkers to identify responder patients to these liposomal agents will improve their treatment efficacies. We carried out pharmacological and histopathological analyses of mouse xenograft models bearing human ovarian cancers (Ca...

BACKGROUND This study aims to characterize the heterogeneity in BMI trajectories and evaluate how different BMI trajectories predict mortality risk in Canadian seniors. METHODS Data came from the Canadian National Population Health Survey (NPHS, 1994-2011) and 1480 individuals aged 65-79 years with at least four BMI records were included in this study. Group-based trajectory model was used to...

In the recent years, intensive research work has been dedicated to prove conditional lower bounds in order to reveal the inner structure of the class P. These conditional lower bounds are based on many popular conjectures on well-studied problems. One of the most heavily used conjectures is the celebrated Strong Exponential Time Hypothesis (SETH). It turns out that conditional hardness proved b...

One of the mechanisms of cisplatin cell cytotoxicity is the mitochondria-associated induction of apoptosis. The morphological or functional change of mitochondria in cisplatin-resistant cells has already been reported. Herein we present additional data describing the mitochondrial genomic and functional changes in cisplatin- resistant cells. Cisplatin increased the level of apoptotic cells in c...

IntroductionOverweight (ov) and obesity (ob) are conditions associated with excess adipose tissue mass. Overweight obese (ov/ob) individuals at an increased risk for chronic complications like diabetes mellitus, cardiovascular disease, liver malignancies, sleep apnoea, osteoarthritis, urinary incontinence, psychosocial issues. The prevalence of ov/ob is increasing globally in South Asia. This r...

Ovarian cancer (OV) is the most common gynaecological worldwide. Immunotherapy has recently been proven to be an effective treatment strategy. The work here attempts produce a prognostic immune-related gene pair (IRGP) signature estimate OV patient survival. Gene Expression Omnibus (GEO) and Cancer Genome Atlas (TCGA) databases provided genetic expression profiles clinical data of patients. Bas...

BACKGROUND Recurrent non-medullary thyroid carcinoma (NMTC) is a rare disease. We initially characterized 27 recurrent NMTC: 13 papillary thyroid cancers (PTC), 10 oncocytic follicular carcinomas (FTC-OV), and 4 non-oncocytic follicular carcinomas (FTC). A validation cohort composed of benign and malignant (both recurrent and non-recurrent) thyroid tumours was subsequently analysed (n = 20). ...

Serpin superfamily proteins, most of which are serine protease inhibitors, share an unusual mechanism rooted in their conserved metastable tertiary structure. Although serpins have been identified in isolated members of archea, bacteria, and plants, a remarkable expansion is found in vertebrates. The chicken protein ovalbumin, a storage protein from egg white, lacking protease inhibitory activi...