Purpose: To investigate inherent information provided by 18F-FDG PET to ameliorate shortcomings of relying on visual inspection or sole SUV measurement in treatment assessing. Patients and methods: Twelve patients with newly diagnosed NSCLC and treated with combined Chemoradiotherapy (CRT) were involved in this study. We analyzed the percentage variation of gray value in every gray level or on ...

BACKGROUND The MGMT is a key tumor suppressor gene and aberrant promoter methylation has been reported in many cancers. However, the relationship between MGMT promoter methylation and ovarian cancer remains controversial. This meta-analysis was first conducted to estimate the clinical significance of MGMT promoter methylation in ovarian carcinoma. METHODS Literature search was performed in th...

carney’s complex is a rare autosomal dominantly inherited multiple endocrine neoplasia syndrome that involves spotty skin pigmentations, recurrent cardiac myxomas, endocrine hyperactivity, pituitary adenomas, peripheral nerve tumors, testicular tumors, and ovarian lesions. we present a case of sudden cardiac death in a 40 year old female with a history of carney’s complex with recurrent cardiac...

Inhibitor of IκB kinases (IKK) are key regulators of NF-κB signaling. Three IKK isoforms-α, β, and ε-have been linked to oncogenesis, yet the precise components of NF-κB signaling in ovarian cancer have not yet been dissected. We surveyed 120 ovarian cancer specimens for IKK-ε expression. Notably, cytoplasmic expression was elevated in metastatic lesions relative to primary tumors (P = 0.03). T...

Inhibitor of IkB kinases (IKK) are key regulators of NF-kB signaling. Three IKK isoforms—a, b, and e—have been linked to oncogenesis, yet the precise components of NF-kB signaling in ovarian cancer have not yet been dissected. We surveyed 120 ovarian cancer specimens for IKK-e expression. Notably, cytoplasmic expression was elevated inmetastatic lesions relative to primary tumors (P1⁄4 0.03). T...

BACKGROUND/PURPOSE It has been observed that disruptions in skin patterns are larger for malignant melanoma (MM) than benign lesions. In order to extend the classification results achieved for 2D skin patterns, this work intends to investigate the feasibility of lesion classification using 3D skin surface texture, in the form of surface normals acquired from a previously built six-light photome...

The purpose of this study is to discuss the surgical treatment for ovarian torsion in children and adolescents with a focus on the procedures of adnexal conservation surgery and its frequency in the literature of the last 10 years. We retrospectively reviewed the medical charts of 127 operative ovarian lesions including 30 ovarian torsions (23.6%) treated in two pediatric centers over a 10-year...

Understanding the biology and molecular pathogenesis of ovarian epithelial cancer (EOC) is key to developing improved diagnostic and prognostic indicators and effective therapies. Although research has traditionally focused on the hypothesis that high-grade serous carcinoma (HGSC) arises from the ovarian surface epithelium (OSE), recent studies suggest that additional sites of origin exist and ...

BACKGROUND AND OBJECTIVE Actinic keratoses (AK) are common premalignant skin lesions that can progress to invasive skin squamous cell carcinoma (sSCC). The subtle accumulation of multiple AK in aging individuals increases the risk of sSCC development, and this underscores the need for efficient treatment and patient follow-up. Our objectives were to develop a method based on color texture analy...