are markers of neurodegeneration in postmortem tissues. It is impossible to determine with certainty using postmortem analysis, whether oxidative stress has a primary role in neurodegeneration or is a secondary end-stage epiphenomenon. Growing evidence suggests that the generation of oxidants does not result simply from an accidental disruption of aerobic metabolism, but rather from an active p...

Simultaneous reduction of N2O in the presence co-existing oxidants, especially NO, from industrial plants, is a challenging task.

Oxidants are compounds capable of withdrawing electrons from target atoms or molecules, thus initiating chemical reactions. In biological systems, oxidative modifications are often related to structural, functional and regulatory changes. Partially reduced oxygen species, also known as oxygen-derived free radicals, represent the most important group of biologically relevant oxidants. Significan...

It has been shown that higher levels of estrogens in females protect them against aging by upregulating the expression of antioxidant longevity-related genes. Phytoestrogens are naturally occurring polycyclic phenols found in certain plants that have weak estrogenic effects due to the fact that they are structurally and functionally similar to 17ß-estradiol, and thus, bind to estradiol receptor...

Hydroxyl radicals (HO*) are derived in Fenton reaction with ferrous salt and H2O2 in acid medium, and at neutral pH, metal-oxyl radicals (M-O*) predominate. Evidence is accumulating that M-O* radicals are also active in oxidation reactions, in addition to metal-oxo (M=O) now shown in many publications. Reactivity of these radicals gives selective oxidized products useful in cellular activities,...

The relationship between enzyme engineers and synthetic organic chemists is simultaneously symbiotic and competitive. Synthetic chemists often find their inspiration in the active sites of enzymes, but celebrate any ability to outmaneuver nature’s catalysts. Scientists who create new enzymes, for their part, are quick to point out how elegantly and rapidly catalytic proteins stitch together mol...