AMA Chen S, Li A, Feng M, et al. The protective effect of Wnt3a on inflammatory response in oxygen-glucose deprivation/reoxygenation (OGD/R) astrocyte model. Folia Neuropathologica. 2023. doi:10.5114/fn.2023.130264. APA Chen, S., Li, A., Feng, M., Zhong, W., Yang, L., & X. (2023). https://doi.org/10.5114/fn.2023.130264 Chicago Su-Qin, Ang Min-Yan Wen-Qing Liu Xiao-Yu and Xing-Er Wu. "The model"...

BACKGROUND AND PURPOSE Experimental evidence supports a major role of increased intracellular calcium [Ca2+]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca2+ rise has not been fully elucidated. To clarify further the role and the origin of Ca2+ in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro mode...

Background and Purpose—Experimental evidence supports a major role of increased intracellular calcium [Ca]i levels in the induction of neuronal damage during cerebral ischemia. However, the source of Ca rise has not been fully elucidated. To clarify further the role and the origin of Ca in cerebral ischemia, we have studied the effects of various pharmacological agents in an in vitro model of o...

Cerebral ischemia‑reperfusion injury (CIRI) refers to the phenomenon that ischemic of brain leads cells, which is further aggravated after recovery blood reperfusion. Dihydromyricetin (DHM) has an effective therapeutic effect on vascular diseases; however, its role in CIRI not been investigated. The oxygen and glucose deprivation/reoxygenation (OGD/R) cell model was used HT22 hippocampal neuron...

We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and activates the stress-activated protein kinase (SEK) pathway. In this study, we hypothesized that 1-methylpropyl 2-imidazolyl disulfide (IV-2), a thioredoxin (TRX) inhibitor, augments glucose deprivation-induced cytotoxicity by promoting c-Jun N-terminal kinase (JNK) act...