In another paper (Resnik and Geiling (1925)) we have described the effect of extracts of the posterior lobe of the pituitary (Armour's Pituitary Liquid) upon the heart of the unanesthetized dog. It was found that this substance quickly produced a period of acceleration followed by a profound slowing of the heart rate associated with depression of auriculo-ventricular conduction. During the slow...

OBJECTIVE To determine the benefit of membrane sweeping at initiation of labor induction in conjunction with formal methods of labor induction. METHODS Two hundred seventy-four women at term with a singleton fetus in cephalic presentation and intact membranes were randomly assigned to receive membrane sweeping or no membrane sweeping at initiation of formal labor induction with either dinopro...

Bidens pilosa L. is an Asteraceae growing in tropical zones, and traditionally utilized worldwide in herbal medicine. The present work is based on its traditional use during child birth as a labour facilitator. In vivo tests of acute toxicity showed a weak toxic effect for both extracts but the toxicity of the ethanol extract (LD(50)=6.15 g/kg) was upper than that of the aqueous extract (LD(50)...

OBJECTIVE Syntometrine is an effective uterotonic agent used in preventing primary postpartum haemorrhage but has adverse effects including nausea, vomiting, hypertension and coronary artery spasm. Carbetocin is a newly developed long-acting oxytocin analogue that might be used as an uterotonic agent. We compare the efficacy and safety of intramuscular (IM) carbetocin with IM syntometrine in pr...

BACKGROUND The efficacy of misoprostol versus oxytocin for reducing blood loss during caesarean section remains unclear. OBJECTIVES To conduct a meta-analysis comparing the efficacy of misoprostol with that of oxytocin in reducing blood loss during caesarean section. SEARCH STRATEGY We searched MEDLINE, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL) and ClinicalTrials....

INTRODUCTION Numerous studies on the early contact between mother and the baby and the time they spend together-common stay stress the fact that these are invaluable for the mothers, infants, family and society in general. The objective of the research. The objective of the research was to establish whether mother benefits from the early contact with her baby and the importance of the time peri...

OBJECTIVES a) To compare the clinical effect of rectal misoprostol with intramuscular syntometrine in reducing blood loss in the third stage of labour b) to determine the severity and incidence of side effects of both drugs and c) to measure blood loss, patient tolerance and acceptance of rectal misoprostol. METHODS One hundred and forty parturients were randomly allocated to receive intramus...

Most of the scanty literature on the major constituents of sow’s milk is old, and nothing has to our knowledge been published on its vitamin composition, with the exception of the fragmentary information about vitamins A and C mentioned below. Probably the main reason for this relative lack of information is the difficulty of obtaining satisfactory samples of sow’s milk. This difficulty is stre...

In this laboratory we have previously employed, as a preliminary step in the isolation of oxytocin and vasopressin from posterior pituitary glands (l-3), the method introduced by Kamm et al. (4) for obtaining a fraction high in oxytocic activity and another high in pressor activity. Further purification involved the use of countercurrent distribution (l-3) and zone electrophoresis (3). We have ...

Background: Cassia italica or Senna is a wild plant distributed in south of Iran. It increased water consumption and has a laxative effect. In traditional medicine this plant has been used for the dysmenorrheal. Objective: In this study we investigated the effect of aqueous extract of Cassia italica on uterus contraction. Materials and Methods: Virgin Wistar rats 200-300g were purchased. After ...