OBJECTIVE High maximum standardized uptake values on [(18)F]-fluoro-2-deoxyglucose positron emission tomography are associated with inferior survival in non-small cell lung cancer. Here, we investigated the biological mechanisms underlying [(18)F]-fluoro-2-deoxyglucose uptake in non-small cell lung cancer. METHODS This study included 133 patients with non-small cell lung cancer (109 with aden...

Ho, Richard C., Oscar Alcazar, Nobuharu Fujii, Michael F. Hirshman, and Laurie J. Goodyear. p38 MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. Am J Physiol Regul Integr Comp Physiol 286: R342–R349, 2004. First published October 30, 2003; 10.1152/ ajpregu.00563.2003.—Skeletal muscle expresses at least three p38 MAPKs ( , , ). Howeve...

Myostatin is a member of the transforming growth factor (TGF)-beta superfamily, known for its ability to inhibit muscle growth. It can also regulate metabolism and glucose uptake in a number of tissues. To determine the mechanism of myostatin's effect on glucose uptake, we evaluated its actions using choriocarcinoma cell lines that are widely used as models for placental cells. Protein and mRNA...

INTRODUCTION The aim of the study was to compare the success rate of an uptake-related ablation protocol in which the dose depends on an I-131 24-h neck uptake measurement and a fixed-dose ablation protocol in which the dose depends on tumour stage. METHODS All differentiated thyroid carcinoma patients with M0 disease who had undergone (near-) total thyroidectomy followed by I-131 ablation we...

zinc (zn) and copper (cu) are essential elements and increased plant growth in low concentrations. while high concentrations of these elements as a limiting factor, can cause adverse symptoms on the plants. in the present study, the uptake of micronutrient and macronutrient by pennyroyal were studied in a zn and cu deficiency and toxicity in soil. three levels of copper (0, 5 and 25 mg/kg) and ...

Minable rock phosphate is a finite resource. Replacing mineral phosphorus (P) fertilizer with P-rich secondary resources is one way to manage P more efficiently, but the importance of physicochemical and microbial soil processes induced by secondary resources for plant P uptake is still poorly understood. Using radioactive-labeling techniques, the fertilization effects of dairy manure, fish slu...

The uptake of [125I]T4 was investigated in cultured anterior pituitary cells isolated from adult fed Wistar rats and cultured for 3 days in medium containing 10% fetal calf serum. Experiments were performed with [125I]T4 (10(5) to 2 x 10(6) cpm; 0.35-7 nM) in medium containing 0.5% or 0.1% BSA. The uptake of [125I]T4 increased with time and showed equilibrium after around 1 h of incubation. The...