In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran. Aspergillus luchuensis MERV10 was used as the parental strain in which to induce genetic variabilities after application of different mixtures as well as doses of muta...

Introduction: Iron deficiency anemia and beta-thalassemia trait are the two most common causes of hypochromic microcytic anemia. There are some discriminating functions (DFs) formula to differentiate these two conditions based on RBC's indices which would be compared the validity of the 14 various indices in this study. Correspond...

A closed colony of Lutzomyia longipalpis was established with specimens collected in the Raposa - Serra do Sol indian reservoir, one of the main foci of visceral leishmaniasis in the State of Roraima, Brazil. Biological observations were made on four generations of a L. longipalpis colony with emphasis on productivity. Aspects studied were the number of laid and retained eggs, and the number of...

Apoptotic cells expose phosphatidylserine on their surface as an "eat me" signal, and macrophages respond by engulfing them. Although several molecules that specifically bind phosphatidylserine have been identified, the molecular mechanism that triggers engulfment remains elusive. Here, using a mouse pro-B cell line, Ba/F3, that grows in suspension, we reconstituted the engulfment of apoptotic ...

Talin is a large flexible rod-shaped protein that activates the integrin family of cell adhesion molecules and couples them to cytoskeletal actin. It exists in both globular and extended conformations, and an intramolecular interaction between the N-terminal F3 FERM subdomain and the C-terminal part of the talin rod contributes to an autoinhibited form of the molecule. Here, we report the solut...

A noncytotoxic protein substance, produced by Streptococcus intermedius, with very potent immunosuppressive properties (F3'EP-Si) was tested for lymphocyte mitogenic activity. Although devoid of T-cell mitogenicity, F3'EP-Si stimulated proliferation and led to high numbers of plaque-forming cells in cultures of normal or T-cell-depleted, small or large splenic B cells from both lipopolysacchari...

In this paper we study the homotopical rotation vectors and the homotopical rotation sets for the billiard flow on the unit flat torus with three, mutually intersecting and mutually orthogonal cylindrical scatterers removed from it. The natural habitat for these objects is the infinite cone erected upon the Cantor set Ends(F3) of all “ends” of the hyperbolic group F3 = π1(Q). An element of Ends...

Factor V Leiden (F5L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5L (F5L/L ) and haploinsufficient for tissue factor pathway inhibitor (Tfpi+/- ). F8 deficiency enhanced the survival of F5L/LTfpi+/-...

Daun sirsak (Annona muricata L.) mengandung flavonoid yang memiliki aktivitas antioksidan sangat kuat . Telah dibuat formula handbody lotion daun masing-masing 0,05% (F1), 0,1% (F2), 0,15% (F3). Tujuan penelitian ini untuk melihat dari ketiga ekstrak etanol (F1, F2, F3) telah dibuat.Uji dilakukan terhadap F1, dan F3 menggunakan metode DPPH dengan menentukan nilai IC 50 formula. Hasil menunjukka...

Cancer genome sequencing has unraveled the huge variety of DNA alterations acquired during cell transformation. Only a small part of these alterations are thought to promote cancer development, while others represent mere random passenger mutations. It is essential to decipher which mutations are driving the oncogenic process to translate cancer sequencing data into clinically meaningful inform...