Squamous cell carcinoma of the head and neck (HNSCC) is a heterogeneous but largely preventable disease with complex molecular abnormalities. It arises from a premalignant progenitor followed by outgrowth of clonal populations associated with cumulative genetic alterations and phenotypic progression to invasive malignancy. These genetic alterations result in inactivation of multiple tumour supp...

BACKGROUND Survival of patients with anaplastic astrocytoma is highly variable. Prognostic markers would thus be useful to identify clinical subsets of such patients. Because specific genetic alterations have been associated with glioblastoma, we investigated whether similar genetic alterations could be detected in patients with anaplastic astrocytoma and used to identify those with particularl...

than inhibiting cell division? The quest to identify means to stop cells from proliferating has driven generations of researchers to investigate the mechanisms regulating the cell division cycle. The cell cycle consists of several phases. Progression from one phase to the next depends on the activity of specific proteins. In order to pass the checkpoints between two phases, several classes of p...

Osteosarcoma (OS) is a common cancerous bone tumor which has a detrimental impact on the lives of patients and their families. The present study aimed at investigating the underlying molecular mechanism of various drug treatments pertaining to OS, including dimethyl sulfoxide (DMSO), doxorubicin (DXP), Nutlin-3, actinomycin D (ActD) and etoposide (Eto). Microarray and p53 chromatin immunoprecip...

The tumor suppressor p53 is inactivated by mutation in about half of all tumors, making mutant a prime target for cancer therapy. Missense mutations R248W, R273H and R248Q are included the five most frequent total lead to more than 630 000 new diagnosed cases diseases world every year. These mutations, located at or near protein-DNA interface, inactivation loss direct p53-DNA interactions, caus...

The tumor suppressor p53 functions predominantly as a transcription factor by activating and downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to indirectly repress transcription of the CCNB2, KIF23 and PLK4 cell cycle genes through the recently discovered p53-p21-DREAM-CDE/CHR pathway. However, it remained unclear whether this pathway is commonly used. He...

coastal region of chah bahar port, sea of oman, was screened for the presence of bioluminescence bacteria for the first time. water samples were taken from surface and subsurface layers and immediately spread on nutrient seawater complete (swc) agar. luminous colonies were observed after an overnight incubation at 25°c. among twenty luminous isolates, four of them were selected for preliminary ...

results approximately 20% of the patients expressed alternatively spliced transcripts of gla mrna involving exon 3. we additionally report that such non-canonical transcripts are physiologically expressed at trace levels in healthy individuals, and that their expression in leukocytes markedly increased in blood samples kept at room-temperature for 48 hours before rna extraction. background defi...