Pain in any context is always associated with high interand intra-individual variability. There are several paininducement methods and numerous pain measurement methods at researchers’ disposal in experimental settings; since none of them is without limitations, the increasing number of researchers decides upon a multimethod approach. In doing so, clarity and unambiguity of the results may vary...

UNLABELLED Prior research has found that pain catastrophizing measured before pain testing is not correlated with the nociceptive flexion reflex (NFR) threshold (a measure of spinal nociception), suggesting that catastrophizing does not alter pain through descending modulatory mechanisms. However, recent evidence suggests that in vivo catastrophizing (measured during or after pain testing) is a...

BACKGROUND Intense abdominal pain is the dominant feature of chronic pancreatitis. During the disease changes in central pain processing, e.g. central sensitization manifest as spreading hyperalgesia, can result from ongoing nociceptive input. The aim of the present study is to evaluate the effect of pregabalin on pain processing in chronic pancreatitis as assessed by quantitative sensory testi...

When the end-point is reached in the HardyWolff method of measuring pain threshold, there is a sharp change in the subjective experience resulting from the stimulus. When the radiation intensity is below the level of the pain threshold, the sensation is one of heat alone. If the pain threshold is exceeded, there is a sensation of heat with an added factor which has been variously described as "...

BACKGROUND The goal of this study was to evaluate whether preoperative pressure pain sensitivity testing is predictive of postoperative surgical pain. METHODS Female subjects undergoing lower abdominal gynecologic surgery were studied. A pressure algometer was used preoperatively to determine the pressure pain threshold and tolerance. A visual analog scale (VAS) was used to assess postoperati...