Super-resolution microscopy coupled with multiplexing techniques can resolve specific spatial arrangements of different components within molecular complexes. However, reliable quantification and analysis of such specific organization is extremely problematic because it is frequently obstructed by random co-localization incidents between crowded molecular species and the intrinsic heterogeneity...

Biological processes are often governed by functional modules of large protein assemblies such as the proteasomes and the nuclear pore complex, for example. However, atomic structures can be determined experimentally only for a small fraction of these multicomponent assemblies. In this article, we present an ant colony optimization based approach to predict the structure of large multicomponent...

Let ∆ be a triangulated homology ball whose boundary complex is ∂∆. A result of Hochster asserts that the canonical module of the Stanley–Reisner ring of ∆, F[∆], is isomorphic to the Stanley–Reisner module of the pair (∆, ∂∆), F[∆, ∂∆]. This result implies that an Artinian reduction of F[∆, ∂∆] is (up to a shift in grading) isomorphic to the Matlis dual of the corresponding Artinian reduction ...

Motivation: Software systems predicting automatically whether and how two proteins may interact are highly desirable, both, for understanding biological processes and for rational design of new proteins. As a part of a future complete solution to this problem a bundle of programs is presented designed (1) to estimate initial docking positions for a given pair of docking candidates, (2) to adjus...

Supramolecular photochemistry as well as solar cells are fascinating topics of current interest in Inorganic Photochemistry and very active research fields which have attracted wide attention in last two decades. A brief outline of the investigations in these fields carried out in our Laboratory of Inorganic Photochemistry and Energy Conversion is given here with no attempt of an exhaustive cov...

Selective formation of bimetallic group 10 complexes using the Cs symmetric, bicyclic diphosphane P2C12H20 is reported herein. With its eclipsed lone pairs disposed at a relative angle of ca. 45 , the diphosphane framework is ideally suited to form multiple bridges between two metal centers. The complexes contain {M2P6} cages with three diphosphane bridges and a pair of trans-axial ligands such...

A wide range of research activities have been carried out so far on benzimidazole and pyridine derivatives to evaluate their Antiviral, Anticancer, Anticonvulsant, Anthelmintic Activity and many promising results are obtained with respect to the anticancer activity. Out of the various ligands used, the alkylating agents are found to be highly active with respect to cancer chemotherapy. Nitrogen...

Motivation: Software systems predicting automatically whether and how two proteins may interact are highly desirable, both, for understanding biological processes and for rational design of new proteins. As a part of a future complete solution to this problem a bundle of programs is presented designed (1) to estimate initial docking positions for a given pair of docking candidates, (2) to adjus...

A new cryptand, bis(1,3,5-phenylene)tri(1,4,7,10-tetraoxadecyl) (3a), has been synthesized in good yield from bis(5-hydroxy-1,3-phenylene)-26-crown-8 (2a) and tri(ethylene glycol) ditosylate using pseudo-high dilution conditions. 3a forms a strong 1:1 complex with paraquat (1) in acetone solution with a high apparent association constant, 1.4 x 10(4) M(-)(1). A stoichiometry of 1:1 was also obs...

Reactions of lithium salts of the bulky guanidinate ligands, [ArNC(NR2)NAr](-) (NR2 = N(C6H11)2 (Giso-) and cis-NC5H8Me2-2,6 (Pipiso-); Ar = C6H3Pri2-2,6), with GeCl2.dioxane afforded the heteroleptic germylenes, [(Giso)GeCl] and [(Pipiso)GeCl], the former of which was structurally characterised. The further reactivity of these and the related complexes, [(Piso)GeCl] and [(Priso)GeCl] (Piso- = ...