Contrasting with improved survival for most other gastrointestinal cancers, the 5-year survival of patients with ductal adenocarcinoma of the pancreas remains low at a dismal 4%. In 2000, an estimated 28,300 patients were diagnosed with pancreatic cancer in the United States These patients can expect to benefit from some progress in management. Minimally invasive procedures such as helical comp...

The differential diagnosis of the focal lesions in the region of the pancreas is difficult due to the similarity of clinical and radiological pictures of neoplastic and non-neoplastic lesions. This paper presents the most common causes of errors in ultrasound diagnosis of pancreatic pathologies. Attention was paid to the errors resulting from the structural variants of the pancreas and those ca...

The pancreas is composed of both exocrine glands and intermingled endocrine cells to execute its diverse functions, including enzyme production for digestion of nutrients and hormone secretion for regulation of blood glucose levels. To define the molecular constituents with elevated expression in the human pancreas, we employed a genome-wide RNA sequencing analysis of the human transcriptome to...

Pancreas transplantation is well recognised and established treatment for selected patients with type-1 diabetes. Furthermore, this treatment remains the only therapeutic modality to offer excellent and reliable glycemia control, without the administration of insulin in type-1 diabetics. It is well documented that combination of pancreas and kidney transplant (i.e. Simultaneous Pancreas and Kid...

IT is well known that pancreatic allografts normalize hyperglycemia a few hours after reperfusion. Endocrine function has been intensively studied in pancreas allografts from a biochemical point of view. Outstanding among functional studies is intravenous (IV) glucagon test, which has rarely been used in pancreas transplantation. However, there is little information on early histochemical aspec...

The pancreas is comprised of epithelial cells that are required for food digestion and blood glucose regulation. Cells of the pancreas microenvironment, including endothelial, neuronal, and mesenchymal cells were shown to regulate cell differentiation and proliferation in the embryonic pancreas. In the adult, the function and mass of insulin-producing cells were shown to depend on cells in thei...

BACKGROUND AND STUDY AIMS The rates for endoscopic detection of pancreas divisum at routine endoscopic retrograde cholangiopancreatography (ERCP) vary worldwide, and the sample sizes in the reported studies on endoscopy and surgery for pancreas divisum are very small and variable. The aim of this study was to systematically analyze the pooled data and determine endoscopic detection rates for pa...

: Biallelic variants in the pancreas-specific transcription factor 1A (PTF1A) gene are a rare cause of permanent neonatal diabetes. We report case diabetes with unique clinical manifestations. The diagnosis affected infant was confirmed by insufficient endocrine and exocrine pancreas activity; however, normal imaging. Molecular analyses identified novel homozygous single nucleotide variant (Chr...