Congenital hyperinsulinism of infancy (CHI) is characterized by severe hypoglycemia due to dysregulated insulin secretion, associated with either focal or diffuse pathology of the endocrine pancreas. The focal condition is caused by a paternally inherited mutation in one of the genes encoding the subunits of the beta-cell ATP-sensitive potassium channel (SUR1/ABCC8 or Kir6.2/KCNJ11) and somatic...

CONTEXT In as much as no such variant of this pancreatic tumour has been previously reported in the literature, we report an unusual case of an adenosquamous carcinoma of the pancreas characterized by clear cells and rhabdoid cells. CASE REPORT A 75-year-old man presented with upper abdominal distention, dyspepsia, jaundice, and significant weight loss over a period of 3 months. Imaging of th...

Adrenocortical carcinosarcoma is an extremely rare and aggressive variant of adrenocortical carcinoma characterized by the presence of both carcinomatous and sarcomatous components, with the latter often showing heterologous differentiation. Due to the rarity and unusual histology, it may pose a diagnostic challenge. In order to increase awareness and identify potential diagnostic pitfalls, we ...

BACKGROUND Somatostatinomas of the gastrointestinal tract secret hormon somatostatin which can cause "inhibitory syndrom" comprising diabetes mellitus, cholelithiasis and steatorrheic diarrhea. It is also secreted by the D cells of Langerhans's islands of the pancreas as well as endocrine cells of the stomack, small bowel, salivary glands and parafollicular cells of the thiroid gland. Somatosta...

Context Intraductal Papillary Mucinous Neoplasm of the pancreas is an increasingly diagnosed neoplasm that rarely penetrates adjacent organs. Case report A sixty-year-old asymptomatic male was seen for evaluation of iron deficiency anemia. Patient was found to have a mucin secreting tumor during esophagogastroduodenoscopy. Computed tomography scan showed an enlarged pancreas with numerous focal...

The present report concerns several post-mortem variables examined in sand rats that were either maintained on a vegetal diet (control animals) or exposed first during a 20-day transition period to a mixed diet consisting of a fixed amount of a hypercaloric food and decreasing amounts of the vegetal food and then to a 30-day experimental period of exposure to the hypercaloric food. During the l...

Synchronous primary cancers involving the pancreas and kidney are extremely rare and poorly documented. We report the first case of this association treated with chemotherapy and tyrosine kinase inhibitor. A 70-year-old woman presented with a 2-month history of epigastric pain with weight loss of 12 kg. Two weeks previously, she had presented with jaundice and pelvic pain. A computed tomography...

OBJECTIVE Increased oxidative stress is associated with the progression of diabetic mellitus. In the present study, we investigated the effects of the ethanolic extract of Nigerian propolis (N. propolis) on markers of oxidative stress, histology of the liver and pancreas and glycaemia in alloxan-induced diabetic rats. MATERIALS AND METHODS Alloxan-induced hyperglycemic Wistar rats were treate...

Extra osseous ewing sarcoma is rare which mainly arise in paravertebral soft tissue and associated with CNS and ewing sarcoma of abdominal viscera is very rare. Only 14 to 18 cases of EES/pPNET arising in the pancreas have been reported so far in literature. We report a case 22 year boy presented with 15 days history of pain and lump abdomen. CT shows 18 *12cm mass in head of pancreas with cent...