HYPOTHESIS Reoperation is safe and benefits patients with persistent and recurrent parathyroid carcinoma. DESIGN Retrospective study. The mean follow-up time was 8.1 years (median, 7 years; range, 1-23 years). SETTING A university tertiary referral center. PATIENTS Eighteen patients treated for parathyroid carcinoma from 1966 to 1999. RESULTS The mean serum calcium level was 13.7 mg/dL ...

Localization of Tc-99m sestamibi (MIBI) by parathyroid adenomas (PA) is well known. Typically the radionuclide washes out slowly from the PAs located in the neck. Rapid washout from some PAs has been reported. Various hypotheses have been postulated for slow and rapid clearance of MIBI from PAs, located in the neck. However, the washout of MIBI from ectopic parathyroid adenoma (EPA) in not well...

The typical method for creating targeted contrast agents requires covalent conjugation of separate targeting and fluorophore domains. In this study, we demonstrate that it is possible create tissuespecific near-infrared fluorophores using the inherent chemical structure. Thus, a single compact molecule performs both targeting and imaging. We use this strategy to solve a major problem in head/ne...

Primary hyperparathyroidism is the most common cause of hypercalcemia, and the treatment is primarily surgical. Because of biochemical screening, more patients now present with asymptomatic primary hyperparathyroidism, and consensus guidelines have been developed for the treatment of these patients. There is now considerable interest in minimally invasive approaches to the treatment of hyperpar...

BACKGROUND The imaging techniques most commonly used in the diagnosis of hyperparathyroidisms are ultrasound and scintigraphy. The diagnostic algorithms vary, depending mainly on the population, and experience of physicians. AIM Aim of the present research was to determine the usefulness of parathyroid scintigraphy and ultrasonography in patients diagnosed for hyperparathyroidism in own mater...

BACKGROUND Optical coherence tomography (OCT) allows tissue histologic-like evaluation, but without tissue fixation or staining. We investigated OCT images from tissues obtained at thyroid and parathyroid surgeries to provide a preliminary assessment as to whether these images contain sufficient information for recognition and differentiation of normal neck tissues. METHODS Normal tissues wer...