Pointing to a visual target in 3-dimensional space requires a neural transformation from a visually derived representation of target location to an appropriate pattern of activity in arm muscles. Previous results suggested that 1 step in this process involves a transformation from a representation of target location to a representation of intended arm orientation, and that the neural implementa...

Why map the cerebellar surface? Because: (i) organization of motor, sensory and cognitive functions in the human cerebellum is poorly understood [1], (ii) the highly-folded structure conceals most of the cortical surface, and (iii) functional data analysis may improve with incorporation of surface organization [2]. We constructed a pipeline for extracting, labelling, and conformally mapping cer...

The topographic organization of motor, sensory and cognitive functions in the human cerebellum is poorly understood, and, owing to its anatomical organization, most of the folial surface is hidden from view. In order to facilitate surface-based analysis of functional activation within the cerebellar cortex, we constructed a "pipeline" for extracting, labelling and conformally mapping the cortic...

introduction: a fixed hemodynamic response function (hrf) is commonly used for functional magnetic resonance imaging (fmri) analysis. however, hrf may vary from region to region and subject to subject. we investigated the effect of locally estimated hrf (in functionally homogenous parcels) on activation detection sensitivity in a heroin cue reactivity study. methods: we proposed a novel explora...

Description: The aim of this project is to run an existing cerebellum parcellation algorithm on a cohort of healthy aging controls. The project will establish normative estimates of volumes for various regions of the cerebellum during the aging process. The project is an opportunity to learn about the anatomy of core portion of the human brain while being engaged in a cutting edge research proj...

The mesencephalic locomotor region (MLR), which includes the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CN), has been recently identified as a key structure for locomotion and gait control in mammals. However, the function and the precise anatomy of the MLR remain unclear in humans. To study the lateral mesencephalus, we used fMRI in 15 right-handed healthy volunteers performing ...