In an earlier study (Van Lieshout and Stein in Math Gesoci 44(3):309–326, 2012) we postulated the existence of two major earthquakes in the 2005 Kashmir disaster instead of a single one, based upon the pattern of aftershocks. In this study, we explore this hypothesis further by fitting several spatial point pattern models. In particular, we discuss the Hawkes and the trigger process models for ...

OBJECTIVES To assess health-related quality of life (HRQoL) and behavior of triplets compared with matched singletons at adolescent age and to identify medical and sociodemographic predictors of outcome. STUDY DESIGN Fifty-four triplets (19 sets, mean [SD] gestational age 32.0 [2.4] weeks, birth weight 1580 [450] g) and 51 gestational age-, birth weight-, and sex-matched singleton controls se...

OBJECTIVE To estimate in a cross sectional analysis the degree of colinearity among the disease activity measures more commonly used in juvenile chronic arthritis (JCA). METHODS This study assessed in a single clinical evaluation three subjective variables, three measures of functional capacity, eight articular indices, and two laboratory indicators of systemic inflammation in 55 consecutive ...

Providing parents with low incomes accused of child maltreatment with legal representation is a basic social justice issue. The Minnesota state public defender’s office ceased representation of parents in child protection cases in 2008. The Child Protection Clinic was established in 2011 at William Mitchell College of Law to help fill this gap and develop standards for representing parents invo...

BACKGROUND The Parent Report of Children's Abilities-Revised (PARCA-R) is a questionnaire for assessing cognitive and language development in very preterm infants. Given the increased risk of developmental delay in infants born late and moderately preterm (LMPT; 32-36 weeks), this study aimed to validate this questionnaire as a screening tool in this population. METHODS Parents of 219 childre...

The germplasm collection of 87 wheat-wheatgrass hybrids developed in Tsitisin Main Botanical Garden (Russia, Moscow) was evaluated for resistance to pre-harvest sprouting (PHS) by spike sprouting (SS) and germination index (GI) assays as well as for spike and grain features. The PHS resistance variation and haplotype polymorphism of the wheatgrass ThVp-1 and wheat TaVp-1B genes orthologues of V...

We study the optimal tax system in a dynamic model where differences in wages induce differences in inheritances, and the transition from parent ability to child ability is described by a Markov chain. In accordance with empirical evidence, we assume that in any generation more able individuals are likely to have a more able parent, which implies that in the steady state they also tend to recei...

MALDI-TOF MS has previously been used for imaging of large peptides and proteins embedded in tissue sections. This imaging technique is not limited to larger molecules, but can also be used to measure the presence of small molecules directly from tissue. However, for small molecule imaging the method of choice is a selected reaction monitoring approach in MS/MS mode.The benefits of parent ion i...

Prodrugs are biologically inactive derivatives of an active drug intended to solve certain problems of the parent drug such as toxicity, instability, minimal solubility and non-targeting capabilities. The majority of drugs for cardiovascular diseases undergo first-pass metabolism, resulting in drug inactivation and generation of toxic metabolites, which makes them appealing targets for prodrug ...

For improved l-serine production, an l-serine dehydratase-defective mutant of Sarcina albida IAM 1012 was obtained. In the mutant, the activities of the enzymes responsible for l-serine production were as high as those in the parent strain, and, at a low glycine concentration, the mutant accumulated l-serine more efficiently than the parent. Under optimum conditions, 21 mg of l-serine per ml ac...