Acral melanoma has been reported to be associated with poorer outcomes than melanoma occurring on other cutaneous sites. It has been suggested that part of this disparity in outcomes may be related to delay in diagnosis. Therefore, we have analyzed the rate of misdiagnoses in patients with melanoma located on the foot and have characterized the influence on the clinical course and survival of t...

this cross sectional study was carried out between 1993 to 1998 at razi skin hospital, the affiliated dermatology department of tehran university of medical sciences. eight hundred patients receiving etretinate for various skin diseases took part in this study. among them, 457 patients with first admission to dermatologic clinic who had at least four regular sequential visits and responding to ...

Onychomycosis is a relatively common dermatologic presentation (Table 1). The incidence of the disease varies regionally and with age. Although in most cases the condition poses no significant long-term health risk, treatment is indicated. Affected nails can be cosmetically unsightly and may become painful and cause functional impairment. In some cases, such as among diabetic patients, treatmen...

Erlotinib is low molecular-weight quinazolin derivatives which selectively inhibit the epidermal growth factor receptor (EGF-R) tyrosine kinase activity of the intracellular domain, block autophosphorylation and the subsequent signaling cascades. EGF-R is expressed on basal keratinocytes, sebocytes, the outer root sheath of hairs, and endothelial cells in the skin, and plays important roles in ...

In July 2008, cetuximab, a monoclonal antibody against epidermal growth factor receptor (EGFR), was approved in Japan for clinical use against chemotherapy-refractory metastatic colorectal cancer (mCRC). At Shiga University of Medical Science, between December 2007 and April 2012, a total of 24 EGFR-positive mCRC cases were administered immunohistochemistry with cetuximab as salvage monotherapy...

A 26-year-old woman presented with a 5-month history of painful oral erosions and a 1-month history of widespread flaccid vesicles over her face and torso. A biopsy specimen of a skin lesion revealed suprabasal acantholysis. The diagnosis of pemphigus vulgaris (PV) was confirmed by a positive intercellular (IC) antibody titer. The patient was treated with prednisolone (30-45 mg/d) combined with...

Erlotinib is a novel oral tyrosine kinase inhibitor targeting the epidermal growth factor receptor (EGFR). Skin reactions are a frequent side-effect of erlotinib therapy with various clinical manifestations such as papulo-pustular rash, xerosis, paronychia and hair changes [1]. We report two patients with advanced solid tumors who were diagnosed with a histologically confirmed cutaneous leukocy...

OBJECTIVE Panitumumab, a fully human monoclonal antibody targeting epidermal growth factor receptor (EGFR), has antitumor activity and an acceptable safety profile in patients with metastatic colorectal cancer (mCRC). This Phase 2 study evaluated efficacy, pharmacokinetics and safety of panitumumab in Japanese patients with mCRC who developed progressive disease during or after fluoropyrimidine...

Cetuximab is an immunoglobulin G1 monoclonal antibody that binds to the extracellular domain of the epidermal growth factor receptor (EGFR) blocking ligand-induced auto-phosphorylation and subsequent receptor mediated signalling.1,2 Cetuximab in combination with chemotherapy is effective in the treatment of EGFR-expressing tumors including metastatic colorectal cancer (mCRC).2,3 EGFR is strongl...