Toxicity bioassays are important tools to determine biological effects of chemical agents on species. The questions remained on, what effects have been imposed on each of the different molecular site of cells by chemical exposure and how to find a pattern for chemical toxicity. To address the questions, HepG2 cell lines were exposed to the different concentrations of cisplatin for 24 hours to r...

The main contributions of this paper can be summarized as follows. First, we compare the Partial Least Squares (PLS) and the Principal Component Analysis (PCA), under fairly general conditions. (In particular, the existence of a true linear regression is not assumed.) We prove that PLS and PCA are equivalent, to within a rst-order approximation, hence providing a theoretical explanation for emp...

Distances matrices are traditionally analyzed with statistical methods that represent distances as maps such as Metric Multidimensional Scaling (MDS), Generalized Procrustes Analysis (GPA), Individual Differences Scaling (INDSCAL), and DISTATIS. MDS analyzes only one distance matrix at a time while GPA, INDSCAL and DISTATIS extract similarities between several distance matrices. However, none o...