White-matter lesion count and volume estimation are key to the diagnosis and monitoring of multiple sclerosis (MS). Automated MS lesion segmentation methods that have been proposed in the past 20 years reach their limits when applied to patients in early disease stages characterized by low lesion load and small lesions. We propose an algorithm to automatically assess MS lesion load (number and ...

Partial nephrectomy-salt hypertension (PN-SH) of the rat is associated with Na volume loading. As the hypertensive state evolves, the renomedullary interstitial cells (RIC) of the renal nubbin undergo major changes, decreasing significantly in number while the remaining ones exhibit degenerative changes. The antihypertensive action of the RIC in the renal nubbin, as measured by transplants of f...

Introduction Tracer kinetic model parameters are frequently used in clinical trials to measure the efficacy of cancer therapeutics. Typically, the parameters are estimated for each voxel within a volume of interest (VOI) that is drawn around the tumour. The mean or median value is then calculated for the VOI and compared at different stages of the treatment. A simultaneous reduction in the tumo...

the problem of steady magnetohydrodynamic boundary layer flow of an electrically conducting nanofluid due to an exponentially permeable stretching sheet with heat source/sink in presence of thermal radiation is numerically investigated. the effect of transverse brownian motion and thermophoresis on heat transfer and nano particle volume fraction considered. the governing partial differential eq...

the purpose of this study was to investigate the effect of heat treatment including solution treatment and aging on the microstructure of cast nickel-based in100 superalloy including size, volume fraction and morphology of primary γ' and different kinds of carbides. for this purpose, different solution heat treatment cycles and a constant aging cycle were implemented on cast ingot samples and t...

Electromagnetic source localization (ESL) provides non-invasive evaluation of brain electrical activity for neurology research and clinical evaluation of neurological disorders such as epilepsy. Accurate ESL results are dependent upon the use of patient specific models of bioelectric conductivity. While the effects of anisotropic conductivities in the skull and white matter have been previously...

UNLABELLED BACKGROUND As is well known, limited spatial resolution leads to partial volume effects (PVE) and consequently to limited signal recovery. Determination of the mean activity concentration of a target structure is thus compromised even at target sizes much larger than the reconstructed spatial resolution. This leads to serious size-dependent underestimates of true signal intensity ...