W hen Aaron Dunn, MD, began seeing patients in his rural Wisconsin practice who couldn’t afford to pay, he wanted to do something about it. “Physicians are in a critical position to lead the change we want to see to make sure everyone has access to the care we can provide to keep everybody healthy,” Dr Dunn said. So he picked up the phone, called the local county health department and said, “He...

“Outcomes Assessment” has become one of the enduring buzzwords of the decade. But it often seems to be like the weather: Everyone talks about it, but relatively few do anything about it. As clinical laboratory scientists, we have repeatedly challenged ourselves to demonstrate that laboratory results affect patient outcome. Yet very few well-done studies have been published. (How many times have...

Hypertension is a clinical situation associated with endothelial dysfunction and increased vascular reactive oxygen species (ROS) formation. The observations that antioxidants, such as Tempol or apocynin, lower the blood pressure in spontaneously hypertensive rats gave rise to the concept that ROS essentially contribute to hypertension. Recent work, however, has sharpened this view, and it is n...

The quality of any scientific journal depends on the its peer review process. Reviewers donate their unpaid time for this activity and usually receive only little recognition. They are, however, selected based expertise, each received is rated by Editors according to quality. We have been impressed reviews undertaken in 2021 despite challenging external circumstances. Our reviewers inestimable ...

Inference (prediction) is believed to be a fundamentally important computational function for biological sensory systems. For example, the Bayesian model of sensory (e.g., visual) signal processing postulates that the cortical networks in the brain encode a probabilistic belief about reality. The belief state (modeled as a posterior distribution in the Bayes’ formalism) is updated based on comp...

Monoclonal antibodies to the nucleoprotein and glycoprotein of infectious haematopoietic necrosis virus (IHNV) were prepared. Hybridomas were selected by ELISA according to the production of murine immunoglobulins. The specificity of the monoclonal antibodies was tested by Western blotting after SDS-PAGE. The monoclonal antibodies reacted only with a panel of nine IHNV isolates differing in ele...