The prevalence of postinfectious glomerulonephritis has decreased in most developed countries. We report the case of a previously healthy, immunocompetent 65-year-old woman who developed acute glomerulonephritis associated with human parvovirus B19 infection. She was referred by her primary care physician for suspected congestive heart failure but she had an elevated creatinine level and an abn...

A clinical association between idiopathic liver disease and parvovirus B19 infection has been observed. Fulminant liver failure, not associated with other liver-tropic viruses, has been attributed to B19 in numerous reports, suggesting a possible role for B19 components in the extensive hepatocyte cytotoxicity observed in this condition. A recent report by Abe and colleagues (Int J Med Sci. 200...

N Engl J Med 2004;350:586-97. Copyright © 2004 Massachusetts Medical Society. vonne cossart, an australian virologist working in london in the mid-1970s, noted an anomalous reaction of a normal blood donor’s serum (occupying position 19 in plate B) in an assay for hepatitis B. When Cossart excised the line of antigen–antibody precipitation, she saw the particles shown in Figure 1A, and in this ...

Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes...

human parvovirus (hpv) b19 induced aplastic crisis in a family leading to the diagnosis of hereditary spherocytosis (hs) is a very rare condition being barely reported in the literature. we herein report a 4-year-old girl, her brother, and their mother who all presented with progressive pallor and jaundice after a febrile illness. the hpv b19 was diagnosed using polymerase chain reaction (pcr) ...

An increased human parvovirus B19 infection rate has been observed in immunocompromised hosts. In this study, we sought to determine the prevalence of parvovirus B19 infection in adult cancer patients receiving multiple courses of systemic chemotherapy. From March 1999 through April 2000, 59 men and 68 women, with a median age of 49 (18 to 79) years, were enrolled in this study. They had receiv...

Human parvovirus B19 is a small DNA virus that is transmitted mainly through contact with respiratory secretion or aerosols, but it may be transmitted to the fetus transplacentally from infected mother leading to many complications mainly fetal hydrops, intrauterine fetal death or spontaneous abortion. In this study we aimed at assessment of the relation between maternal human parvovirus B19 in...

Little information is available on the immune response to parvovirus B19 after the administration of contaminated blood products. In the present study, we found that levels of B19 IgG in B19-seropositive recipients protect against reinfection and, after transfusion with pooled plasma containing B19 DNA (1.6 x 10(8) IU/mL), increase from 19-39 IU/mL to 50-100 IU/mL. We found that, in the presenc...

Human parvovirus B19 is a well-known cause of severe conditions in patients with sickle cell disease, but the molecular mechanisms of the infection are insufficiently understood. The different clinical outcome of the acute parvovirus B19 infection in two pediatric patients with sickle cell disease has been examined. One of them developed life-threatening condition requiring emergency transfusio...