Meiosis resembles mitosis but employs a unique "reductional" nuclear division to allow the production of haploid gametes from diploid cells. The crucial ploidy reduction step requires that sister kinetochores attach to microtubules emanating from the same spindle pole, achieving "monopolar attachment," which ensures that maternal and paternal chromosomes are segregated. Here we screened for fac...

The current investigation examined whether attachment functioning might mediate the effects of parenting on traits associated with psychopathy. Participants completed the Parental Bonding Instrument, the Experiences in Close Relationships Scale, and the Triarchic Psychopathy Measure within a cross-sectional design. Whilst several recalled parenting variables demonstrated significant correlation...

The analysis of cell-free fetal nucleic acids in maternal blood for prenatal diagnosis has been transformed by several recent profound technology developments. The most noteworthy of these are 'digital PCR' and 'next-generation sequencing' (NGS), which might finally deliver the long-sought goal of noninvasive detection of fetal aneuploidy. Recent data, however, indicate that NGS might even be a...

Fetomaternal alloimmune thrombocytopenia (FMAIT) is caused by maternal generation of antibodies specific for paternal platelet antigens and can lead to fetal intracranial hemorrhage. A SNP in the gene encoding integrin beta3 causes a clinically important maternal-paternal antigenic difference; Leu33 generates the human platelet antigen 1a (HPA-1a), whereas Pro33 generates HPA-1b. As a potential...

During pregnancy in larger mammals, the maternal immune system must tolerate the fetus for months while resisting external infection. This tolerance is facilitated by immunological communication between the fetus and the mother, which is mediated by Major Histocompatibility Complex I (MHC I) proteins, by leukocytes, and by the cytokines secreted by the leukocytes. Fetal-maternal immunological c...

AIM/HYPOTHESIS Maternal diabetes and high-fat feeding during pregnancy have been linked to later life outcomes in offspring. To investigate the effects of both maternal and paternal hyperglycemia on offspring phenotypes, we utilized an autosomal dominant mouse model of diabetes (hypoinsulinemic hyperglycemia in Akita mice). We determined metabolic and skeletal phenotypes in wildtype offspring o...

Background & aim: One of the factors of affecting maternal anxiety is a history of fetal death or neonatal death. This anxiety affects fetal and maternal health. By consideration the impact of anxiety on fetal and maternal health and the lack of protective activities in this field, this study was done to determine the impact of adaptation with pregnancy educational package on anxiety and matern...

Background of the study: The earliest relationship does not begin at birth. concept prenatal attachment is defined as subjective feeling state love for unborn child. Developing an one’s child considered important milestone in future parents’ developmental trajectory. Pregnancy a natural, pleasant process woman’s life, which also associated with significant stresses due to physical and mental ch...