Respiratory pathogens such as influenza and SARS-CoV-2 can cause severe lung infections leading to acute respiratory distress syndrome (ARDS). The pathophysiology of ARDS includes an excessive host immune response, epithelial endothelial cell death loss the barrier integrity, culminating in pulmonary oedema failure. Traditional approaches for treatment include drugs that exert direct anti-patho...

The fungal pathogen Sclerotinia sclerotiorum (Lib.) de Bary is worldwide in distribution and pathogenic to more than 400 plant species. This disease causes significant yield losses of various important crops including sunflower, canola, and soybean. Applying fungicides and crop rotation are currently the major methods of controlling this disease. However, fungicide chemicals are expensive, not ...

Salicylic acid (SA) is a defense hormone required for both local and systemic acquired resistance (SAR) in plants. Pathogen infections induce SA synthesis through up-regulating the expression of Isochorismate Synthase 1 (ICS1), which encodes a key enzyme in SA production. Here we report that both SAR Deficient 1 (SARD1) and CBP60g are key regulators for ICS1 induction and SA synthesis. Whereas ...

The recent cloning of plant resistance (R) genes and the sequencing of resistance gene clusters have shed light on the molecular evolution of R genes. However, up to now, no attempt has been made to correlate this molecular evolution with the host-pathogen coevolution process at the population level. Cross-inoculations were carried out between 26 strains of the fungal pathogen Colletotrichum li...

Our previous observation that host plant extracts induce production and secretion of mannitol in the tobacco pathogen Alternaria alternata suggested that, like their animal counterparts, plant pathogenic fungi might produce the reactive oxygen quencher mannitol as a means of suppressing reactive oxygen-mediated plant defenses. The concurrent discovery that pathogen attack induced mannitol dehyd...

The model presented here modifies a susceptible-infected (SI) host-pathogen model to determine the influence of mating system on the outcome of a host-pathogen interaction. Both deterministic and stochastic (individual-based) versions of the model were used. This model considers the potential consequences of varying mating systems on the rate of spread of both the pathogen and resistance allele...

ABSTRACT: The bacteria Aeromonassp. are naturally reported in aquatic ecosystems and possess pathogenic potential, being considered as emerging pathogens humans animals. They also cause considerable losses fish farming and, through water, can contaminate numerous foods. This study quantified analyzed the antimicrobial resistance profile of fish. A total 72 samples two varieties (leather fish, P...

Grasslands cover 40% of the earth’s surface and support animal-based industries; maintain soil cover, watersheds and biodiversity; sequester atmospheric carbon for storage in the soil; and provide tourism and leisure income. Diseases continue to decrease herbage and seed yield and reduce nutritive value and palatability of grasslands to impact on animal health and productivity but realistic dat...