BACKGROUND Exposure to lead (Pb) from environmental and industrial sources remains an overlooked serious public health risk. Elucidating the effect of Pb on bone cell function is therefore critical for understanding its risk associated with diseases of low bone mass. OBJECTIVES We tested the hypothesis that Pb negatively affects bone mass. We also assessed the underlying mechanisms of Pb on b...

Exposures to lead (Pb) are associated with neurological problems including psychiatric disorders and impaired learning and memory. Pb can be absorbed by iron transporters, which are up-regulated in hereditary hemochromatosis, an iron overload disorder in which increased iron deposition in various parenchymal organs promote metal-induced oxidative damage. While dysfunction in HFE (High Fe) gene ...

The toxicity of Pb and Cd+Pb was assessed on the Collembola F. candida in two cultivated soils (SV and AU) with low organic matter (OM) content and circumneutral to basic pH, and an acid forested soil (EPC) with high OM content. Collembola reproduction and growth as well as metal content in Collembola body, in soil, exchangeable fraction and soil solutions, pH and DOC were investigated. Pb and ...

Our earlier studies showed that lactational exposure to lead (Pb) caused irreversible neurochemical alterations in rats. The present study was carried out to examine whether gestational exposure to Pb can cause long-term changes in the brain cholinergic system and behavior of rats. The protective effect of calcium (Ca) supplementation against Pb toxicity was also examined. Pregnant rats were ex...

The first reports of ψ and ψ production from experiment NA50 at the CERN SPS are compared to predictions based on a hadronic model of charmonium suppression. Data on centrality dependence and total cross sections are in good accord with these predictions. This manuscript has been authored under contract number DE-AC02-76CH00016 with the U. S. Department of Energy. Accordingly, the U.S. Governme...

The systematics of Statistical Model parameters extracted from heavy-ion collisions at lower energies are exploited to extrapolate in the LHC regime. Predictions of various particle ratios are presented and particle production in central Pb-Pb collisions at LHC is discussed in the context of the Statistical Model. The sensitivity of several ratios on the temperature and the baryon chemical pote...

S. Hegyi, C. Höhne, K. Kadija, A. Karev, D. Kikola, M. Kliemant, S. Kniege, V.I. Kolesnikov, E. Kornas, R. Korus, M. Kowalski, I. Kraus, M. Kreps, A. László, R. Lacey, M. van Leeuwen, P. Lévai, L. Litov, B. Lungwitz, M. Makariev, A.I. Malakhov, M. Mateev, G.L. Melkumov, C. Meurer, A. Mischke, M. Mitrovski, J. Molnár, St. Mrówczyński, V. Nicolic, G. Pálla, A.D. Panagiotou, D. Panayotov, A. Petri...

The aim of this study is to investigate the use of keratin colloidal solution, which was obtained from wool, for the removal of Pb(II) from water. The addition of keratin colloidal solution (15 g L(-1), 0.30 mL) to a Pb(II) solution (1.0 mM, 0.90 mL, pH 5.0) resulted in the formation and precipitation of a Pb-keratin aggregate. Measurement of the Pb(II) and protein concentrations in the superna...

The mechanism of Pb-induced disruption of Na(+) and Cl(-) balance was investigated in the freshwater rainbow trout (Oncorhynchus mykiss). Na(+) and Cl(-) influx rates were reduced immediately in the presence of 2.40 +/- 0.24 and 1.25 +/- 0.14 muM Pb, with a small increase in efflux rates occurring after 24-h exposure. Waterborne Pb caused a significant decrease in the maximal rate of Na(+) infl...

Lead arsenate was used on orchard soils as a pesticide from 1900 to 1960. An in vitro method has been used to determine the bioaccessiblity of Pb in soils contaminated by Pb paint, fossil fuel combustion, and metallurgical industries. The Pb fraction that is potentially bioavailable from orchard soils, however, has not been reported. Potential reductions in availability of Pb and As as a result...